DegronMD - P47985(UQCRFS1)

FUNCTION: [Cytochrome b-c1 complex subunit Rieske, mitochondrial]: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:31883641). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (PubMed:28673544). {ECO:0000250|UniProtKB:P08067, ECO:0000269|PubMed:28673544, ECO:0000269|PubMed:31883641}.; FUNCTION: [Cytochrome b-c1 complex subunit 9]: Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function. {ECO:0000269|PubMed:28673544}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R92H	TCGA-56-8082	LUSC	TCGA	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.2222
p.R92H	DO225346	BRCA	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.2222
p.R92H	DO223722	LUSC	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.2222
p.R92H	SIDM00500	Colorectal Carcinoma	GDSC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.2222
p.I83T	TCGA-AJ-A5DW	UCEC	TCGA	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation altering degron motif	0.5966
p.I83T	DO50075	UCEC	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation altering degron motif	0.5966
p.D82Y	TCGA-AP-A1DV	UCEC	TCGA	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation altering degron motif	0.6214
p.D82Y	DO43186	UCEC	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation altering degron motif	0.6214
p.P86S	TCGA-D9-A4Z3	SKCM	TCGA	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation altering degron motif	0.6752
p.P86S	DO47555	SKCM	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation altering degron motif	0.6752
p.S75F	TCGA-DA-A1IC	SKCM	TCGA	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.2222
p.S75F	DO37430	SKCM	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.2222
p.R93H	TCGA-SW-A7EA	STAD	TCGA	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.R93H	DO233888	GACA	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.R93H	DO51749	STAD	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.R93H	SIDM00216	Colorectal Carcinoma	GDSC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.R93H	SIDM00602	Gastric Carcinoma	GDSC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.R93H	ACH-000919	Gastric Cancer	CCLE	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.R93H	ACH-000989	Colon/Colorectal Cancer	CCLE	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.R93H	SNU-175	large intestine	COSMIC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.R93H	IM-95	stomach	COSMIC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.1944
p.S89C	TCGA-UY-A9PB	BLCA	TCGA	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.3056
p.S89C	DO219041	BLCA	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.3056
p.I83V	DO228488	BRCA	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation altering degron motif	0.5965
p.R92C	DO230347	COCA	ICGC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.2222
p.R92C	SIDM00177	Melanoma	GDSC	SHTDIKVPDF	DEG_COP1_1	79:88	Mutation rewiring degron network	0.2222

Kaplan plot for UQCRFS1 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

UQCRFS1

UniProt ID: P47985

Entrez ID: 7386

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UQCRFS1 in