DegronMD

Uniprot ID: P47985

Source protein: Cytochrome b-c1 complex subunit Rieske, mitochondrial

Source gene: UQCRFS1

Class: DEG_COP1_1

Location: 79:88

E3 ligase: COP1

DEGRON score: 0.9829

ASA_SCORE: 72.01

COIL: 0.7602

CONS_SCORE: 0.372

DSS_SCORE: 0.1983

HELIX: 0.1026

FCONS_SCORE: 1.2054

RIG_SCORE: 0.8218

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R92H	TCGA-56-8082	LUSC	TCGA	SHTDIKVPDF	DEG_COP1_1	0.2222
p.R92H	DO225346	BRCA	ICGC	SHTDIKVPDF	DEG_COP1_1	0.2222
p.R92H	DO223722	LUSC	ICGC	SHTDIKVPDF	DEG_COP1_1	0.2222
p.R92H	SIDM00500	Colorectal Carcinoma	GDSC	SHTDIKVPDF	DEG_COP1_1	0.2222
p.I83T	TCGA-AJ-A5DW	UCEC	TCGA	SHTDIKVPDF	DEG_COP1_1	0.5966
p.I83T	DO50075	UCEC	ICGC	SHTDIKVPDF	DEG_COP1_1	0.5966
p.D82Y	TCGA-AP-A1DV	UCEC	TCGA	SHTDIKVPDF	DEG_COP1_1	0.6214
p.D82Y	DO43186	UCEC	ICGC	SHTDIKVPDF	DEG_COP1_1	0.6214
p.P86S	TCGA-D9-A4Z3	SKCM	TCGA	SHTDIKVPDF	DEG_COP1_1	0.6752
p.P86S	DO47555	SKCM	ICGC	SHTDIKVPDF	DEG_COP1_1	0.6752
p.S75F	TCGA-DA-A1IC	SKCM	TCGA	SHTDIKVPDF	DEG_COP1_1	0.2222
p.S75F	DO37430	SKCM	ICGC	SHTDIKVPDF	DEG_COP1_1	0.2222
p.R93H	TCGA-SW-A7EA	STAD	TCGA	SHTDIKVPDF	DEG_COP1_1	0.1944
p.R93H	DO233888	GACA	ICGC	SHTDIKVPDF	DEG_COP1_1	0.1944
p.R93H	DO51749	STAD	ICGC	SHTDIKVPDF	DEG_COP1_1	0.1944
p.R93H	SIDM00216	Colorectal Carcinoma	GDSC	SHTDIKVPDF	DEG_COP1_1	0.1944
p.R93H	SIDM00602	Gastric Carcinoma	GDSC	SHTDIKVPDF	DEG_COP1_1	0.1944
p.R93H	ACH-000919	Gastric Cancer	CCLE	SHTDIKVPDF	DEG_COP1_1	0.1944
p.R93H	ACH-000989	Colon/Colorectal Cancer	CCLE	SHTDIKVPDF	DEG_COP1_1	0.1944
p.R93H	SNU-175	large_intestine	COSMIC	SHTDIKVPDF	DEG_COP1_1	0.1944
p.R93H	IM-95	stomach	COSMIC	SHTDIKVPDF	DEG_COP1_1	0.1944
p.S89C	TCGA-UY-A9PB	BLCA	TCGA	SHTDIKVPDF	DEG_COP1_1	0.3056
p.S89C	DO219041	BLCA	ICGC	SHTDIKVPDF	DEG_COP1_1	0.3056
p.I83V	DO228488	BRCA	ICGC	SHTDIKVPDF	DEG_COP1_1	0.5965
p.R92C	DO230347	COCA	ICGC	SHTDIKVPDF	DEG_COP1_1	0.2222
p.R92C	SIDM00177	Melanoma	GDSC	SHTDIKVPDF	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47985	Cytochrome b-c1 complex subunit Rieske, mitochondrial	DEG_COP1_1	79:88	SHTDIKVPDF	COP1	0.9829	More...
P0C7P4	Putative cytochrome b-c1 complex subunit Rieske-like protein 1	DEG_COP1_1	88:97	SHTDIKVPDF	COP1	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons