DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
SHTDIKVPDF
Uniprot ID:
P0C7P4
Source protein:
Putative cytochrome b-c1 complex subunit Rieske-like protein 1
Source gene:
UQCRFS1P1
Class:
DEG_COP1_1
Location:
88:97
E3 ligase:
COP1
DEGRON score:
0.9829
ASA_SCORE:
68.96
COIL:
0.774
CONS_SCORE:
0.3975
DSS_SCORE:
0.1975
HELIX:
0.1023
FCONS_SCORE:
1.2401
RIG_SCORE:
0.8216
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with UQCRFS1P1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of SHTDIKVPDF
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P47985
Cytochrome b-c1 complex subunit Rieske, mitochondrial
DEG_COP1_1
79:88
SHTDIKVPDF
COP1
0.9829
More...
P0C7P4
Putative cytochrome b-c1 complex subunit Rieske-like protein 1
DEG_COP1_1
88:97
SHTDIKVPDF
COP1
0.9829
More...