DegronMD - P47989(XDH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D557N	TCGA-16-0848	GBM	TCGA	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.3056
p.D557N	DO229005	COCA	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.3056
p.D557N	DO12196	GBM	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.3056
p.D557N	SIDM00282	Colorectal Carcinoma	GDSC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.3056
p.D557N	SIDM01753	Gastric Carcinoma	GDSC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.3056
p.D557N	CW-2	large intestine	COSMIC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.3056
p.Q559H	TCGA-29-1688	OV	TCGA	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation altering degron motif	0.647
p.Q559H	DO28026	OV	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation altering degron motif	0.647
p.P565S	TCGA-2W-A8YY	CESC	TCGA	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.2778
p.P565S	DO223732	CESC	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.2778
p.M573I	TCGA-BF-AAOU	SKCM	TCGA	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.0556
p.M573I	DO219460	SKCM	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.0556
p.Q562K	TCGA-CC-A7IJ	LIHC	TCGA	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation altering degron motif	0.5833
p.Q562K	DO52183	LIHC	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation altering degron motif	0.5833
p.F550L	DO233819	GACA	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.1111
p.P555T	DO228531	LICA	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.25
p.L560I	DO229036	LICA	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation altering degron motif	0.6063
p.P554S	DO220877	MELA	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.2222
p.P554S	DO222632	MELA	ICGC	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.2222
p.S569C	ACH-001608	Brain Cancer	CCLE	VQLFQE	LIG_APCC_ABBA_1	558:563	Mutation rewiring degron network	0.1667

Kaplan plot for XDH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

XDH

UniProt ID: P47989

Entrez ID: 7498

Protein name: Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase (XD) (EC 1.17.1.4); Xanthine oxidase (XO) (EC 1.17.3.2) (Xanthine oxidoreductase) (XOR)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for XDH in