DegronMD

Uniprot ID: P47989

Source protein: Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase

Source gene: XDH

Class: LIG_APCC_ABBA_1

Location: 558:563

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8564

ASA_SCORE: 70.4167

COIL: 0.4228

CONS_SCORE: 0.2992

DSS_SCORE: 0.61

HELIX: 0.0863

FCONS_SCORE: 1.0101

RIG_SCORE: 0.788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D557N	TCGA-16-0848	GBM	TCGA	VQLFQE	LIG_APCC_ABBA_1	0.3056
p.D557N	DO229005	COCA	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.3056
p.D557N	DO12196	GBM	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.3056
p.D557N	SIDM00282	Colorectal Carcinoma	GDSC	VQLFQE	LIG_APCC_ABBA_1	0.3056
p.D557N	SIDM01753	Gastric Carcinoma	GDSC	VQLFQE	LIG_APCC_ABBA_1	0.3056
p.D557N	CW-2	large_intestine	COSMIC	VQLFQE	LIG_APCC_ABBA_1	0.3056
p.Q559H	TCGA-29-1688	OV	TCGA	VQLFQE	LIG_APCC_ABBA_1	0.647
p.Q559H	DO28026	OV	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.647
p.P565S	TCGA-2W-A8YY	CESC	TCGA	VQLFQE	LIG_APCC_ABBA_1	0.2778
p.P565S	DO223732	CESC	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.2778
p.M573I	TCGA-BF-AAOU	SKCM	TCGA	VQLFQE	LIG_APCC_ABBA_1	0.0556
p.M573I	DO219460	SKCM	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.0556
p.Q562K	TCGA-CC-A7IJ	LIHC	TCGA	VQLFQE	LIG_APCC_ABBA_1	0.5833
p.Q562K	DO52183	LIHC	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.5833
p.F550L	DO233819	GACA	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.1111
p.P555T	DO228531	LICA	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.25
p.L560I	DO229036	LICA	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.6063
p.P554S	DO220877	MELA	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.2222
p.P554S	DO222632	MELA	ICGC	VQLFQE	LIG_APCC_ABBA_1	0.2222
p.S569C	ACH-001608	Brain Cancer	CCLE	VQLFQE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P47989	Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	LIG_APCC_ABBA_1	558:563	VQLFQE	APC,CDC20,FZR1	0.8564	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons