DegronMD - P48169(GABRA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S513Y	TCGA-05-5425	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1389
p.S513Y	DO26270	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1389
p.G514D	TCGA-44-6775	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1111
p.G514D	TCGA-GM-A2DD	BRCA	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1111
p.G514D	DO1313	BRCA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1111
p.G514D	DO24517	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1111
p.G497V	TCGA-55-A492	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2778
p.G497V	DO23708	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2778
p.G497W	TCGA-55-A492	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2778
p.G497W	DO23708	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2778
p.G494W	TCGA-64-5781	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.G494W	TCGA-VQ-A8PY	STAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.G494W	DO23740	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.G494W	DO51779	STAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.V490F	TCGA-78-7155	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0833
p.V490F	DO23590	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0833
p.P509R	TCGA-83-5908	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.25
p.P509R	DO23572	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.25
p.S511F	TCGA-DK-AA76	BLCA	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.S511F	DO219013	BLCA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.G512E	TCGA-EE-A2MD	SKCM	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1667
p.G512E	DO222434	MELA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1667
p.G512E	DO37851	SKCM	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1667
p.G494R	TCGA-FR-A726	SKCM	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.G494R	DO48665	SKCM	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.P503A	TCGA-N9-A4Q7	UCS	TCGA	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation altering degron motif	0.7503
p.P504A	DO50435	ESAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation altering degron motif	0.6392
p.T489K	DO229027	LICA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0556
p.P508L	DO220872	MELA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2778
p.S516R	SIDM00135	Breast Carcinoma	GDSC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0556
p.S516R	ACH-000148	Breast Cancer	CCLE	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0556
p.S516R	Hs-578-T	breast	COSMIC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0556
p.P508T	SIDM00474	Ovarian Carcinoma	GDSC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2778
p.I493T	SIDM01045	Endometrial Carcinoma	GDSC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1667
p.I493T	ACH-000978	Endometrial/Uterine Cancer	CCLE	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1667
p.I493T	EN	endometrium	COSMIC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1667
p.T515A	SIDM00217	Colorectal Carcinoma	GDSC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0833
p.T515A	SNU-1040	large intestine	COSMIC	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.0833
p.P505L	ACH-001623	Brain Cancer	CCLE	LSATPPPS	DEG_SCF_FBW7_1	499:506	Mutation altering degron motif	0.6471

Kaplan plot for GABRA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GABRA4

UniProt ID: P48169

Entrez ID: 2557

Protein name: Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GABRA4 in