DegronMD

Uniprot ID: P48169

Source protein: Gamma-aminobutyric acid receptor subunit alpha-4

Source gene: GABRA4

Class: DEG_SCF_FBW7_1

Location: 499:506

E3 ligase: FBXW7

DEGRON score: 0.5878

ASA_SCORE: 84.3125

COIL: 0.9221

CONS_SCORE: 0.2458

DSS_SCORE: 0.6874

HELIX: 0.0253

FCONS_SCORE: 0.8477

RIG_SCORE: 0.6107

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S513Y	TCGA-05-5425	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.1389
p.S513Y	DO26270	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1389
p.G514D	TCGA-44-6775	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.1111
p.G514D	TCGA-GM-A2DD	BRCA	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.1111
p.G514D	DO1313	BRCA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1111
p.G514D	DO24517	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1111
p.G497V	TCGA-55-A492	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.2778
p.G497V	DO23708	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.2778
p.G497W	TCGA-55-A492	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.2778
p.G497W	DO23708	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.2778
p.G494W	TCGA-64-5781	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.1944
p.G494W	TCGA-VQ-A8PY	STAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.1944
p.G494W	DO23740	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1944
p.G494W	DO51779	STAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1944
p.V490F	TCGA-78-7155	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.0833
p.V490F	DO23590	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.0833
p.P509R	TCGA-83-5908	LUAD	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.25
p.P509R	DO23572	LUAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.25
p.S511F	TCGA-DK-AA76	BLCA	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.1944
p.S511F	DO219013	BLCA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1944
p.G512E	TCGA-EE-A2MD	SKCM	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.1667
p.G512E	DO222434	MELA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1667
p.G512E	DO37851	SKCM	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1667
p.G494R	TCGA-FR-A726	SKCM	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.1944
p.G494R	DO48665	SKCM	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.1944
p.P503A	TCGA-N9-A4Q7	UCS	TCGA	LSATPPPS	DEG_SCF_FBW7_1	0.7503
p.P504A	DO50435	ESAD	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.6392
p.T489K	DO229027	LICA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.0556
p.P508L	DO220872	MELA	ICGC	LSATPPPS	DEG_SCF_FBW7_1	0.2778
p.S516R	SIDM00135	Breast Carcinoma	GDSC	LSATPPPS	DEG_SCF_FBW7_1	0.0556
p.S516R	ACH-000148	Breast Cancer	CCLE	LSATPPPS	DEG_SCF_FBW7_1	0.0556
p.S516R	Hs-578-T	breast	COSMIC	LSATPPPS	DEG_SCF_FBW7_1	0.0556
p.P508T	SIDM00474	Ovarian Carcinoma	GDSC	LSATPPPS	DEG_SCF_FBW7_1	0.2778
p.I493T	SIDM01045	Endometrial Carcinoma	GDSC	LSATPPPS	DEG_SCF_FBW7_1	0.1667
p.I493T	ACH-000978	Endometrial/Uterine Cancer	CCLE	LSATPPPS	DEG_SCF_FBW7_1	0.1667
p.I493T	EN	endometrium	COSMIC	LSATPPPS	DEG_SCF_FBW7_1	0.1667
p.T515A	SIDM00217	Colorectal Carcinoma	GDSC	LSATPPPS	DEG_SCF_FBW7_1	0.0833
p.T515A	SNU-1040	large_intestine	COSMIC	LSATPPPS	DEG_SCF_FBW7_1	0.0833
p.P505L	ACH-001623	Brain Cancer	CCLE	LSATPPPS	DEG_SCF_FBW7_1	0.6471

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LSATPPPS

Degron related mutations and impact score

Drug responses associated with GABRA4 mutations

All proteins holding degron of LSATPPPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48169	Gamma-aminobutyric acid receptor subunit alpha-4	DEG_SCF_FBW7_1	499:506	LSATPPPS	FBXW7	0.5878	More...