IREB2
UniProt ID: P48200
Entrez ID: 3658
Protein name: Iron-responsive element-binding protein 2 (IRE-BP 2) (Iron regulatory protein 2) (IRP2)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression ...
FUNCTION: RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. {ECO:0000269|PubMed:7983023}.
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GO - Biological processes (BP):
cellular iron ion homeostasis [GO:0006879]; citrate metabolic process [GO:0006101]; erythrocyte homeostasis [GO:0034101]; intestinal absorption [GO:0050892]; iron ion homeostasis [GO:0055072]; iron ion transport [GO:0006826]; osteoclast differentiation [GO:0030316]; post-embryonic development [GO:00...
cellular iron ion homeostasis [GO:0006879]; citrate metabolic process [GO:0006101]; erythrocyte homeostasis [GO:0034101]; intestinal absorption [GO:0050892]; iron ion homeostasis [GO:0055072]; iron ion transport [GO:0006826]; osteoclast differentiation [GO:0030316]; post-embryonic development [GO:0009791]; protoporphyrinogen IX biosynthetic process [GO:0006782]; tricarboxylic acid cycle [GO:0006099]
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GO - Molecular function (MF):
4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371]...
4 iron, 4 sulfur cluster binding [GO:0051539]; aconitate hydratase activity [GO:0003994]; iron-responsive element binding [GO:0030350]; metal ion binding [GO:0046872]; RNA binding [GO:0003723]; translation repressor activity [GO:0030371]
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GO - Cellular component (CC):
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]...
cytoplasm [GO:0005737]; cytosol [GO:0005829]; mitochondrion [GO:0005739]
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IREB2
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Kaplan plot for IREB2 in
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*NOTE: the Kaplan plots were collected from OncoLnc