DegronMD

Uniprot ID: P48200

Source protein: Iron-responsive element-binding protein 2

Source gene: IREB2

Class: DEG_Kelch_Keap1_1

Location: 177:182

E3 ligase: KEAP1

DEGRON score: 0.9473

ASA_SCORE: 54.1667

COIL: 0.6333

CONS_SCORE: 0.151

DSS_SCORE: 0.3899

HELIX: 0.2543

FCONS_SCORE: 0.992

RIG_SCORE: 0.6901

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G184V	TCGA-BT-A20N	BLCA	TCGA	SCDSGE	DEG_Kelch_Keap1_1	0.2778
p.G184V	DO550	BLCA	ICGC	SCDSGE	DEG_Kelch_Keap1_1	0.2778
p.R175Q	TCGA-FW-A3R5	SKCM	TCGA	SCDSGE	DEG_Kelch_Keap1_1	0.2778
p.R175Q	DO37406	SKCM	ICGC	SCDSGE	DEG_Kelch_Keap1_1	0.2778
p.S177F	TCGA-W3-A824	SKCM	TCGA	SCDSGE	DEG_Kelch_Keap1_1	0.9093
p.S177F	DO51271	SKCM	ICGC	SCDSGE	DEG_Kelch_Keap1_1	0.9093
p.G188V	DO228976	LICA	ICGC	SCDSGE	DEG_Kelch_Keap1_1	0.1667
p.R185Q	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	SCDSGE	DEG_Kelch_Keap1_1	0.25
p.R185Q	ACH-002101	Lung Cancer	CCLE	SCDSGE	DEG_Kelch_Keap1_1	0.25
p.R185Q	EMC-BAC-1	lung	COSMIC	SCDSGE	DEG_Kelch_Keap1_1	0.25
p.C168R	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	SCDSGE	DEG_Kelch_Keap1_1	0.0833
p.C168R	ACH-000416	Lung Cancer	CCLE	SCDSGE	DEG_Kelch_Keap1_1	0.0833
p.C168R	NCI-H838	lung	COSMIC	SCDSGE	DEG_Kelch_Keap1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48200	Iron-responsive element-binding protein 2	DEG_Kelch_Keap1_1	177:182	SCDSGE	KEAP1	0.9473	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons