DegronMD - P48443(RXRG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A31E	TCGA-43-6143	LUSC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.0833
p.A31E	DO26428	LUSC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.0833
p.R54Q	TCGA-A5-A1OF	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1944
p.R54Q	TCGA-BR-4361	STAD	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1944
p.R54Q	TCGA-D9-A6EA	SKCM	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1944
p.R54Q	DO50290	SKCM	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1944
p.R54Q	DO38887	STAD	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1944
p.R54Q	DO42568	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1944
p.T46A	TCGA-BS-A0UF	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.7139
p.T46A	DO41488	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.7139
p.T48N	TCGA-CN-6992	HNSC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5944
p.T48N	DO14606	HNSC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5944
p.P53R	TCGA-CR-6487	HNSC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2222
p.P53R	DO15527	HNSC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2222
p.D47E	TCGA-CS-6665	LGG	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5647
p.D47E	DO22287	LGG	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5647
p.D40Y	TCGA-EO-A3AV	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.7325
p.D40Y	DO52412	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.7325
p.D47N	TCGA-GN-A266	SKCM	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5821
p.D47N	DO37432	SKCM	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5821
p.T55I	DO50444	ESAD	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1667
p.P38R	DO45037	LINC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.G36E	DO219878	SKCA	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2222
p.S30L	SIDM00798	Rhabdomyosarcoma	GDSC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.0556
p.S30L	ACH-000201	Rhabdoid	CCLE	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.0556
p.S30L	ACH-001212	Rhabdoid	CCLE	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.0556
p.S30L	A204	soft tissue	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.0556
p.P38A	SIDM00878	Breast Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38A	ACH-000930	Breast Cancer	CCLE	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38A	HCC1569	breast	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38S	SIDM01146	Gastric Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38S	ACH-000932	Gastric Cancer	CCLE	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38S	NCI-SNU-1	stomach	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.S57N	SIDM00989	Bladder Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1111
p.S57N	ACH-000802	Bladder Cancer	CCLE	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1111
p.S57N	BFTC-905	urinary tract	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1111
p.A58E	SIDM00162	Biliary Tract Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.0833
p.A58E	ACH-000268	Bile Duct Cancer	CCLE	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.0833
p.E34K	ChaGo-K-1	lung	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.1667
p.F39L	HCC2998	large intestine	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.3056

Kaplan plot for RXRG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RXRG

UniProt ID: P48443

Entrez ID: 6258

Protein name: Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RXRG in