DegronMD - P48443(RXRG)

FUNCTION: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). {ECO:0000250}.

GO - Biological processes (BP): anatomical structure development [GO:0048856]; cell differentiation [GO:0030154]; heart development [GO:0007507]; neuron differentiation [GO:0030182]; peripheral nervous system development [GO:0007422]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of myelination... View more >>

GO - Molecular function (MF): DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981]; nuclear receptor activity [GO:0004879]; retinoic acid-responsive element binding [GO:0044323]; RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978]; sequence-specific double-stranded DNA... View more >>

GO - Cellular component (CC): chromatin [GO:0000785]; cytoplasm [GO:0005737]; nucleoplasm [GO:0005654]; RNA polymerase II transcription regulator complex [GO:0090575]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D40Y	TCGA-EO-A3AV	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.7325
p.D40Y	DO52412	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.7325
p.T46A	TCGA-BS-A0UF	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.7139
p.T46A	DO41488	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.7139
p.T48N	TCGA-CN-6992	HNSC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5944
p.T48N	DO14606	HNSC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5944
p.D47N	TCGA-GN-A266	SKCM	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5821
p.D47N	DO37432	SKCM	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5821
p.D47E	TCGA-CS-6665	LGG	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5647
p.D47E	DO22287	LGG	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation altering degron motif	0.5647
p.F39L	HCC2998	large intestine	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.3056
p.P38R	DO45037	LINC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38A	SIDM00878	Breast Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38A	ACH-000930	Breast Cancer	CCLE	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38A	HCC1569	breast	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38S	SIDM01146	Gastric Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38S	ACH-000932	Gastric Cancer	CCLE	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P38S	NCI-SNU-1	stomach	COSMIC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2778
p.P53R	TCGA-CR-6487	HNSC	TCGA	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2222
p.P53R	DO15527	HNSC	ICGC	DSHPSYTDTP	CBL_PTK	40:49	Mutation rewiring degron network	0.2222

Showing 1 to 20 of 40 entries

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Kaplan plot for RXRG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RXRG

UniProt ID: P48443

Entrez ID: 6258

Protein name: Retinoic acid receptor RXR-gamma (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RXRG in