DegronMD

Degron: DSHPSYTDTP

Uniprot ID: P48443

Source protein: Retinoic acid receptor RXR-gamma

Source gene: RXRG

Class: CBL_PTK

Location: 40:49

E3 ligase: CBL

DEGRON score: 0.9973

ASA_SCORE: 76.37

COIL: 0.9065

CONS_SCORE: 0.475

DSS_SCORE: 0.6079

HELIX: 0.0265

FCONS_SCORE: 1.1165

RIG_SCORE: 0.6326

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D40Y	TCGA-EO-A3AV	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	0.7325
p.D40Y	DO52412	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	0.7325
p.T46A	TCGA-BS-A0UF	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	0.7139
p.T46A	DO41488	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	0.7139
p.T48N	TCGA-CN-6992	HNSC	TCGA	DSHPSYTDTP	CBL_PTK	0.5944
p.T48N	DO14606	HNSC	ICGC	DSHPSYTDTP	CBL_PTK	0.5944
p.D47N	TCGA-GN-A266	SKCM	TCGA	DSHPSYTDTP	CBL_PTK	0.5821
p.D47N	DO37432	SKCM	ICGC	DSHPSYTDTP	CBL_PTK	0.5821
p.D47E	TCGA-CS-6665	LGG	TCGA	DSHPSYTDTP	CBL_PTK	0.5647
p.D47E	DO22287	LGG	ICGC	DSHPSYTDTP	CBL_PTK	0.5647
p.F39L	HCC2998	large_intestine	COSMIC	DSHPSYTDTP	CBL_PTK	0.3056
p.P38R	DO45037	LINC	ICGC	DSHPSYTDTP	CBL_PTK	0.2778
p.P38A	SIDM00878	Breast Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	0.2778
p.P38A	ACH-000930	Breast Cancer	CCLE	DSHPSYTDTP	CBL_PTK	0.2778
p.P38A	HCC1569	breast	COSMIC	DSHPSYTDTP	CBL_PTK	0.2778
p.P38S	SIDM01146	Gastric Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	0.2778
p.P38S	ACH-000932	Gastric Cancer	CCLE	DSHPSYTDTP	CBL_PTK	0.2778
p.P38S	NCI-SNU-1	stomach	COSMIC	DSHPSYTDTP	CBL_PTK	0.2778
p.P53R	TCGA-CR-6487	HNSC	TCGA	DSHPSYTDTP	CBL_PTK	0.2222
p.P53R	DO15527	HNSC	ICGC	DSHPSYTDTP	CBL_PTK	0.2222
p.G36E	DO219878	SKCA	ICGC	DSHPSYTDTP	CBL_PTK	0.2222
p.R54Q	TCGA-A5-A1OF	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	0.1944
p.R54Q	TCGA-BR-4361	STAD	TCGA	DSHPSYTDTP	CBL_PTK	0.1944
p.R54Q	TCGA-D9-A6EA	SKCM	TCGA	DSHPSYTDTP	CBL_PTK	0.1944
p.R54Q	DO50290	SKCM	ICGC	DSHPSYTDTP	CBL_PTK	0.1944

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Drug responses associated with RXRG mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of DSHPSYTDTP

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48443	Retinoic acid receptor RXR-gamma	CBL_PTK	40:49	DSHPSYTDTP	CBL	0.9973	More...

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