DegronMD

Uniprot ID: P48443

Source protein: Retinoic acid receptor RXR-gamma

Source gene: RXRG

Class: CBL_PTK

Location: 40:49

E3 ligase: CBL

DEGRON score: 0.9973

ASA_SCORE: 76.37

COIL: 0.9065

CONS_SCORE: 0.475

DSS_SCORE: 0.6079

HELIX: 0.0265

FCONS_SCORE: 1.1165

RIG_SCORE: 0.6326

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A31E	TCGA-43-6143	LUSC	TCGA	DSHPSYTDTP	CBL_PTK	0.0833
p.A31E	DO26428	LUSC	ICGC	DSHPSYTDTP	CBL_PTK	0.0833
p.R54Q	TCGA-A5-A1OF	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	0.1944
p.R54Q	TCGA-BR-4361	STAD	TCGA	DSHPSYTDTP	CBL_PTK	0.1944
p.R54Q	TCGA-D9-A6EA	SKCM	TCGA	DSHPSYTDTP	CBL_PTK	0.1944
p.R54Q	DO50290	SKCM	ICGC	DSHPSYTDTP	CBL_PTK	0.1944
p.R54Q	DO38887	STAD	ICGC	DSHPSYTDTP	CBL_PTK	0.1944
p.R54Q	DO42568	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	0.1944
p.T46A	TCGA-BS-A0UF	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	0.7139
p.T46A	DO41488	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	0.7139
p.T48N	TCGA-CN-6992	HNSC	TCGA	DSHPSYTDTP	CBL_PTK	0.5944
p.T48N	DO14606	HNSC	ICGC	DSHPSYTDTP	CBL_PTK	0.5944
p.P53R	TCGA-CR-6487	HNSC	TCGA	DSHPSYTDTP	CBL_PTK	0.2222
p.P53R	DO15527	HNSC	ICGC	DSHPSYTDTP	CBL_PTK	0.2222
p.D47E	TCGA-CS-6665	LGG	TCGA	DSHPSYTDTP	CBL_PTK	0.5647
p.D47E	DO22287	LGG	ICGC	DSHPSYTDTP	CBL_PTK	0.5647
p.D40Y	TCGA-EO-A3AV	UCEC	TCGA	DSHPSYTDTP	CBL_PTK	0.7325
p.D40Y	DO52412	UCEC	ICGC	DSHPSYTDTP	CBL_PTK	0.7325
p.D47N	TCGA-GN-A266	SKCM	TCGA	DSHPSYTDTP	CBL_PTK	0.5821
p.D47N	DO37432	SKCM	ICGC	DSHPSYTDTP	CBL_PTK	0.5821
p.T55I	DO50444	ESAD	ICGC	DSHPSYTDTP	CBL_PTK	0.1667
p.P38R	DO45037	LINC	ICGC	DSHPSYTDTP	CBL_PTK	0.2778
p.G36E	DO219878	SKCA	ICGC	DSHPSYTDTP	CBL_PTK	0.2222
p.S30L	SIDM00798	Rhabdomyosarcoma	GDSC	DSHPSYTDTP	CBL_PTK	0.0556
p.S30L	ACH-000201	Rhabdoid	CCLE	DSHPSYTDTP	CBL_PTK	0.0556
p.S30L	ACH-001212	Rhabdoid	CCLE	DSHPSYTDTP	CBL_PTK	0.0556
p.S30L	A204	soft_tissue	COSMIC	DSHPSYTDTP	CBL_PTK	0.0556
p.P38A	SIDM00878	Breast Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	0.2778
p.P38A	ACH-000930	Breast Cancer	CCLE	DSHPSYTDTP	CBL_PTK	0.2778
p.P38A	HCC1569	breast	COSMIC	DSHPSYTDTP	CBL_PTK	0.2778
p.P38S	SIDM01146	Gastric Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	0.2778
p.P38S	ACH-000932	Gastric Cancer	CCLE	DSHPSYTDTP	CBL_PTK	0.2778
p.P38S	NCI-SNU-1	stomach	COSMIC	DSHPSYTDTP	CBL_PTK	0.2778
p.S57N	SIDM00989	Bladder Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	0.1111
p.S57N	ACH-000802	Bladder Cancer	CCLE	DSHPSYTDTP	CBL_PTK	0.1111
p.S57N	BFTC-905	urinary_tract	COSMIC	DSHPSYTDTP	CBL_PTK	0.1111
p.A58E	SIDM00162	Biliary Tract Carcinoma	GDSC	DSHPSYTDTP	CBL_PTK	0.0833
p.A58E	ACH-000268	Bile Duct Cancer	CCLE	DSHPSYTDTP	CBL_PTK	0.0833
p.E34K	ChaGo-K-1	lung	COSMIC	DSHPSYTDTP	CBL_PTK	0.1667
p.F39L	HCC2998	large_intestine	COSMIC	DSHPSYTDTP	CBL_PTK	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSHPSYTDTP

Degron related mutations and impact score

Drug responses associated with RXRG mutations

All proteins holding degron of DSHPSYTDTP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48443	Retinoic acid receptor RXR-gamma	CBL_PTK	40:49	DSHPSYTDTP	CBL	0.9973	More...