DegronMD - P48506(GCLC)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R196K	TCGA-17-Z027	LUAD	TCGA	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0833
p.K211N	TCGA-F5-6814	READ	TCGA	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation blocking ubiquitination signal	0.75
p.K211N	DO36556	READ	ICGC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation blocking ubiquitination signal	0.75
p.S215P	DO1092	BRCA	ICGC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation blocking phosphorylation signal	0.6389
p.I218V	SIDM00845	Burkitt's Lymphoma	GDSC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1111
p.P216A	SIDM00505	Pancreatic Carcinoma	GDSC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.P216A	MIA-PaCa-2	pancreas	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.I214V	DND-41	haematopoietic and lymphoid tissue	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.G206E	Mewo	skin	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.7199
p.A217D	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.V199M	LU-165	lung	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.D213Y	OVK-18	ovary	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.25
p.V214M	LU-165	lung	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.Q198H	BC-3	haematopoietic and lymphoid tissue	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.M207I	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.7618
p.N219S	IGROV-1	ovary	COSMIC	VPIFKD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0833

Kaplan plot for GCLC in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GCLC

UniProt ID: P48506

Entrez ID: 2729

Protein name: Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for GCLC in