DegronMD

Uniprot ID: P48506

Source protein: Glutamate--cysteine ligase catalytic subunit

Source gene: GCLC

Class: LIG_APCC_ABBA_1

Location: 205:210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.983

ASA_SCORE: 58.7667

COIL: 0.6722

CONS_SCORE: 0.6463

DSS_SCORE: 0.4017

HELIX: 0.1097

FCONS_SCORE: 1.1311

RIG_SCORE: 0.8157

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R196K	TCGA-17-Z027	LUAD	TCGA	VPIFKD	LIG_APCC_ABBA_1	0.0833
p.K211N	TCGA-F5-6814	READ	TCGA	VPIFKD	LIG_APCC_ABBA_1	0.75
p.K211N	DO36556	READ	ICGC	VPIFKD	LIG_APCC_ABBA_1	0.75
p.S215P	DO1092	BRCA	ICGC	VPIFKD	LIG_APCC_ABBA_1	0.6389
p.I218V	SIDM00845	Burkitt's Lymphoma	GDSC	VPIFKD	LIG_APCC_ABBA_1	0.1111
p.P216A	SIDM00505	Pancreatic Carcinoma	GDSC	VPIFKD	LIG_APCC_ABBA_1	0.1667
p.P216A	MIA-PaCa-2	pancreas	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.1667
p.I214V	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.2222
p.G206E	Mewo	skin	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.7199
p.A217D	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.1389
p.V199M	LU-165	lung	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.1667
p.D213Y	OVK-18	ovary	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.25
p.V214M	LU-165	lung	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.2222
p.Q198H	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.1389
p.M207I	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.7618
p.N219S	IGROV-1	ovary	COSMIC	VPIFKD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48506	Glutamate--cysteine ligase catalytic subunit	LIG_APCC_ABBA_1	205:210	VPIFKD	APC,CDC20,FZR1	0.983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons