DegronMD - P49590(HARS2)

HARS2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L66R	TCGA-34-5232	LUSC	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.25
p.L66R	DO27168	LUSC	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.25
p.V72A	TCGA-BR-8487	STAD	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.V72A	DO47867	STAD	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0833
p.E51D	TCGA-BS-A0UF	UCEC	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1944
p.E51D	TCGA-CA-6717	COAD	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1944
p.E51D	DO8264	COAD	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1944
p.E51D	DO41488	UCEC	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1944
p.T59P	TCGA-D5-6540	COAD	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.8142
p.T59P	DO9708	COAD	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.8142
p.F55C	TCGA-DK-A6AW	BLCA	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.3056
p.F55C	DO48566	BLCA	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.3056
p.K52T	DO222798	COCA	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation blocking ubiquitination signal	0.6667
p.M71I	DO229045	LICA	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1111
p.R59C	VMRC-LCD	lung	COSMIC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.8301
p.A51T	SHP-77	lung	COSMIC	IIKTPKGT	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc