DegronMD

Uniprot ID: P49590

Source protein: Histidine--tRNA ligase, mitochondrial

Source gene: HARS2

Class: DEG_SCF_FBW7_1

Location: 56:63

E3 ligase: FBXW7

DEGRON score: 0.9481

ASA_SCORE: 54.1125

COIL: 0.9009

CONS_SCORE: 0.5572

DSS_SCORE: 0.4711

HELIX: 0.0156

FCONS_SCORE: 1.3957

RIG_SCORE: 0.7445

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L66R	TCGA-34-5232	LUSC	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	0.25
p.L66R	DO27168	LUSC	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	0.25
p.V72A	TCGA-BR-8487	STAD	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	0.0833
p.V72A	DO47867	STAD	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	0.0833
p.E51D	TCGA-BS-A0UF	UCEC	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	0.1944
p.E51D	TCGA-CA-6717	COAD	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	0.1944
p.E51D	DO8264	COAD	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	0.1944
p.E51D	DO41488	UCEC	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	0.1944
p.T59P	TCGA-D5-6540	COAD	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	0.8142
p.T59P	DO9708	COAD	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	0.8142
p.F55C	TCGA-DK-A6AW	BLCA	TCGA	IIKTPKGT	DEG_SCF_FBW7_1	0.3056
p.F55C	DO48566	BLCA	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	0.3056
p.K52T	DO222798	COCA	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	0.6667
p.M71I	DO229045	LICA	ICGC	IIKTPKGT	DEG_SCF_FBW7_1	0.1111
p.R59C	VMRC-LCD	lung	COSMIC	IIKTPKGT	DEG_SCF_FBW7_1	0.8301
p.A51T	SHP-77	lung	COSMIC	IIKTPKGT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49590	Histidine--tRNA ligase, mitochondrial	DEG_SCF_FBW7_1	56:63	IIKTPKGT	FBXW7	0.9481	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons