DegronMD - P49754(VPS41)

FUNCTION: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes (PubMed:23351085, PubMed:33851776). Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo (PubMed:9159129, PubMed:23167963, PubMed:25445562, PubMed:25908847). Required for fusion of autophagosomes with lysosomes (PubMed:25783203). Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion (PubMed:25445562, PubMed:25908847, PubMed:21802320). Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS (PubMed:23322049). Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway (PubMed:24210660). {ECO:0000250|UniProtKB:D3ZVH6, ECO:0000269|PubMed:21802320, ECO:0000269|PubMed:23167963, ECO:0000269|PubMed:23322049, ECO:0000269|PubMed:25445562, ECO:0000269|PubMed:25783203, ECO:0000269|PubMed:25908847, ECO:0000269|PubMed:33851776, ECO:0000269|PubMed:9159129, ECO:0000305|PubMed:23167963, ECO:0000305|PubMed:23351085, ECO:0000305|PubMed:24210660, ECO:0000305|PubMed:25445562}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R611H	TCGA-AX-A0J1	UCEC	TCGA	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.R611H	DO27807	MALY	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.R611H	DO41199	UCEC	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.R611H	SIDM00646	Small Cell Lung Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.R611H	SIDM00676	Bladder Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.D624N	TCGA-BR-6709	STAD	TCGA	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.2778
p.D624N	DO38356	STAD	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.2778
p.R611C	TCGA-BR-8680	STAD	TCGA	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.R611C	TCGA-EO-A22R	UCEC	TCGA	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.R611C	DO47769	STAD	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.R611C	DO42713	UCEC	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1667
p.Y623N	TCGA-BR-A4CS	STAD	TCGA	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.3056
p.Y623N	DO47965	STAD	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.3056
p.P630S	TCGA-D3-A8GI	SKCM	TCGA	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.P630S	DO50284	SKCM	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.P630L	TCGA-EE-A181	SKCM	TCGA	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.P630L	DO37444	SKCM	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.P630L	SIDM00608	Plasma Cell Myeloma	GDSC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.P630L	ACH-000714	Myeloma	CCLE	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.P630L	KMS-11	haematopoietic and lymphoid tissue	COSMIC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1111
p.E614K	TCGA-VQ-A924	STAD	TCGA	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.25
p.E614K	DO51795	STAD	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.25
p.N627K	DO221547	PACA	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.1944
p.Y623H	DO221547	PACA	ICGC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.3056
p.Y623H	SIDM02020	Esophageal Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation rewiring degron network	0.3056
p.S618N	SIDM00781	Colorectal Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation altering degron motif	0.5958
p.S618N	SIDM00780	Colorectal Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation altering degron motif	0.5958
p.S618N	SNU-C2B	large intestine	COSMIC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation altering degron motif	0.5958
p.I621V	NOS-1	bone	COSMIC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation altering degron motif	0.7076
p.I621V	KYSE-70	oesophagus	COSMIC	ISLYAE	LIG_APCC_ABBA_1	617:622	Mutation altering degron motif	0.7076

Kaplan plot for VPS41 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

VPS41

UniProt ID: P49754

Entrez ID: 27072

Protein name: Vacuolar protein sorting-associated protein 41 homolog (S53)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for VPS41 in