DegronMD

Uniprot ID: P49754

Source protein: Vacuolar protein sorting-associated protein 41 homolog

Source gene: VPS41

Class: LIG_APCC_ABBA_1

Location: 617:622

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9013

ASA_SCORE: 47.5667

COIL: 0.0688

CONS_SCORE: 0.5605

DSS_SCORE: 0.29

HELIX: 0.9172

FCONS_SCORE: 1.2786

RIG_SCORE: 0.8095

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R611H	TCGA-AX-A0J1	UCEC	TCGA	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.R611H	DO27807	MALY	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.R611H	DO41199	UCEC	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.R611H	SIDM00646	Small Cell Lung Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.R611H	SIDM00676	Bladder Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.D624N	TCGA-BR-6709	STAD	TCGA	ISLYAE	LIG_APCC_ABBA_1	0.2778
p.D624N	DO38356	STAD	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.2778
p.R611C	TCGA-BR-8680	STAD	TCGA	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.R611C	TCGA-EO-A22R	UCEC	TCGA	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.R611C	DO47769	STAD	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.R611C	DO42713	UCEC	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.1667
p.Y623N	TCGA-BR-A4CS	STAD	TCGA	ISLYAE	LIG_APCC_ABBA_1	0.3056
p.Y623N	DO47965	STAD	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.3056
p.P630S	TCGA-D3-A8GI	SKCM	TCGA	ISLYAE	LIG_APCC_ABBA_1	0.1111
p.P630S	DO50284	SKCM	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.1111
p.P630L	TCGA-EE-A181	SKCM	TCGA	ISLYAE	LIG_APCC_ABBA_1	0.1111
p.P630L	DO37444	SKCM	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.1111
p.P630L	SIDM00608	Plasma Cell Myeloma	GDSC	ISLYAE	LIG_APCC_ABBA_1	0.1111
p.P630L	ACH-000714	Myeloma	CCLE	ISLYAE	LIG_APCC_ABBA_1	0.1111
p.P630L	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	ISLYAE	LIG_APCC_ABBA_1	0.1111
p.E614K	TCGA-VQ-A924	STAD	TCGA	ISLYAE	LIG_APCC_ABBA_1	0.25
p.E614K	DO51795	STAD	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.25
p.N627K	DO221547	PACA	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.1944
p.Y623H	DO221547	PACA	ICGC	ISLYAE	LIG_APCC_ABBA_1	0.3056
p.Y623H	SIDM02020	Esophageal Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	0.3056
p.S618N	SIDM00781	Colorectal Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	0.5958
p.S618N	SIDM00780	Colorectal Carcinoma	GDSC	ISLYAE	LIG_APCC_ABBA_1	0.5958
p.S618N	SNU-C2B	large_intestine	COSMIC	ISLYAE	LIG_APCC_ABBA_1	0.5958
p.I621V	NOS-1	bone	COSMIC	ISLYAE	LIG_APCC_ABBA_1	0.7076
p.I621V	KYSE-70	oesophagus	COSMIC	ISLYAE	LIG_APCC_ABBA_1	0.7076

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ISLYAE

Degron related mutations and impact score

Drug responses associated with VPS41 mutations

All proteins holding degron of ISLYAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49754	Vacuolar protein sorting-associated protein 41 homolog	LIG_APCC_ABBA_1	617:622	ISLYAE	APC,CDC20,FZR1	0.9013	More...