DegronMD - P49802(RGS7)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E255K	TCGA-23-1111	OV	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1667
p.P248T	TCGA-33-AASD	LUSC	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.5919
p.P246T	TCGA-55-8506	LUAD	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7031
p.T245S	TCGA-62-A470	LUAD	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7116
p.E257Q	TCGA-86-8076	LUAD	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1111
p.D236N	TCGA-DA-A1HV	SKCM	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1667
p.L258S	TCGA-DI-A1BU	UCEC	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.0833
p.E255D	TCGA-DU-6392	LGG	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1667
p.G232S	TCGA-FR-A44A	SKCM	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.0556
p.S241N	TCGA-FR-A726	SKCM	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation blocking phosphorylation signal	0.75
p.R238K	TCGA-WE-A8K5	SKCM	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.2222
p.E252K	DO225101	BRCA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.25
p.E252K	DO48300	ESCA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.25
p.P238S	DO222786	ESCA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.2222
p.R245Q	DO233853	GACA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7329
p.R245Q	DO220893	MELA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7329
p.D251N	DO233944	GACA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.2778
p.S239R	DO15270	HNSC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.25
p.S239R	DO24409	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.25
p.R242W	DO228813	LICA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.8634
p.G249C	DO24576	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.76
p.A234E	DO218944	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1111
p.G247V	DO23705	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7532
p.G247C	DO23705	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.76
p.W246C	DO24850	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7
p.D256Y	DO231204	LUSC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1389
p.E252V	DO26465	LUSC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.25
p.S235C	DO220852	MELA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1389
p.G259E	DO220902	MELA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.0556
p.E233K	DO37406	SKCM	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.0833
p.E237D	DO47749	STAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1944
p.S235I	DO42384	UCEC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1389
p.G247S	DO41584	UCEC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.6993
p.H240Q	SIDM00776	Colorectal Carcinoma	GDSC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.2778
p.H240Q	ACH-000501	Colon/Colorectal Cancer	CCLE	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.2778
p.H240Q	LS-123	large intestine	COSMIC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.2778
p.R238G	SIDM00636	Non-Cancerous	GDSC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.2222
p.R238G	MC-CAR	haematopoietic and lymphoid tissue	COSMIC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.2222
p.T245I	SIDM00844	Burkitt's Lymphoma	GDSC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7078
p.T245I	ACH-000654	Lymphoma	CCLE	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7078
p.T245I	Raji	haematopoietic and lymphoid tissue	COSMIC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7078
p.T254I	SIDM01679	Small Cell Lung Carcinoma	GDSC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1944
p.T254I	ACH-000523	Lung Cancer	CCLE	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation rewiring degron network	0.1944
p.P242Q	DU-145	prostate	COSMIC	PTHTPTPE	DEG_SCF_FBW7_2	242:249	Mutation altering degron motif	0.7035

Kaplan plot for RGS7 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RGS7

UniProt ID: P49802

Entrez ID: 6000

Protein name: Regulator of G-protein signaling 7 (RGS7)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for RGS7 in