DegronMD

Uniprot ID: P49802

Source protein: Regulator of G-protein signaling 7

Source gene: RGS7

Class: DEG_SCF_FBW7_2

Location: 242:249

E3 ligase: FBXW7

DEGRON score: 0.5046

ASA_SCORE: 86.85

COIL: 0.9176

CONS_SCORE: 0.3282

DSS_SCORE: 0.8457

HELIX: 0.0255

FCONS_SCORE: 0.9618

RIG_SCORE: 0.5601

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E255K	TCGA-23-1111	OV	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.1667
p.P248T	TCGA-33-AASD	LUSC	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.5919
p.P246T	TCGA-55-8506	LUAD	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.7031
p.T245S	TCGA-62-A470	LUAD	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.7116
p.E257Q	TCGA-86-8076	LUAD	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.1111
p.D236N	TCGA-DA-A1HV	SKCM	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.1667
p.L258S	TCGA-DI-A1BU	UCEC	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.0833
p.E255D	TCGA-DU-6392	LGG	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.1667
p.G232S	TCGA-FR-A44A	SKCM	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.0556
p.S241N	TCGA-FR-A726	SKCM	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.75
p.R238K	TCGA-WE-A8K5	SKCM	TCGA	PTHTPTPE	DEG_SCF_FBW7_2	0.2222
p.E252K	DO225101	BRCA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.25
p.E252K	DO48300	ESCA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.25
p.P238S	DO222786	ESCA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.2222
p.R245Q	DO233853	GACA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.7329
p.R245Q	DO220893	MELA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.7329
p.D251N	DO233944	GACA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.2778
p.S239R	DO15270	HNSC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.25
p.S239R	DO24409	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.25
p.R242W	DO228813	LICA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.8634
p.G249C	DO24576	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.76
p.A234E	DO218944	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.1111
p.G247V	DO23705	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.7532
p.G247C	DO23705	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.76
p.W246C	DO24850	LUAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.7
p.D256Y	DO231204	LUSC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.1389
p.E252V	DO26465	LUSC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.25
p.S235C	DO220852	MELA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.1389
p.G259E	DO220902	MELA	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.0556
p.E233K	DO37406	SKCM	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.0833
p.E237D	DO47749	STAD	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.1944
p.S235I	DO42384	UCEC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.1389
p.G247S	DO41584	UCEC	ICGC	PTHTPTPE	DEG_SCF_FBW7_2	0.6993
p.H240Q	SIDM00776	Colorectal Carcinoma	GDSC	PTHTPTPE	DEG_SCF_FBW7_2	0.2778
p.H240Q	ACH-000501	Colon/Colorectal Cancer	CCLE	PTHTPTPE	DEG_SCF_FBW7_2	0.2778
p.H240Q	LS-123	large_intestine	COSMIC	PTHTPTPE	DEG_SCF_FBW7_2	0.2778
p.R238G	SIDM00636	Non-Cancerous	GDSC	PTHTPTPE	DEG_SCF_FBW7_2	0.2222
p.R238G	MC-CAR	haematopoietic_and_lymphoid_tissue	COSMIC	PTHTPTPE	DEG_SCF_FBW7_2	0.2222
p.T245I	SIDM00844	Burkitt's Lymphoma	GDSC	PTHTPTPE	DEG_SCF_FBW7_2	0.7078
p.T245I	ACH-000654	Lymphoma	CCLE	PTHTPTPE	DEG_SCF_FBW7_2	0.7078
p.T245I	Raji	haematopoietic_and_lymphoid_tissue	COSMIC	PTHTPTPE	DEG_SCF_FBW7_2	0.7078
p.T254I	SIDM01679	Small Cell Lung Carcinoma	GDSC	PTHTPTPE	DEG_SCF_FBW7_2	0.1944
p.T254I	ACH-000523	Lung Cancer	CCLE	PTHTPTPE	DEG_SCF_FBW7_2	0.1944
p.P242Q	DU-145	prostate	COSMIC	PTHTPTPE	DEG_SCF_FBW7_2	0.7035

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTHTPTPE

Degron related mutations and impact score

Drug responses associated with RGS7 mutations

All proteins holding degron of PTHTPTPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49802	Regulator of G-protein signaling 7	DEG_SCF_FBW7_2	242:249	PTHTPTPE	FBXW7	0.5046	More...