DegronMD - P49916(LIG3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P256L	TCGA-AZ-6598	COAD	TCGA	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1111
p.P256L	DO10276	COAD	ICGC	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1111
p.P256L	SIDM00663	Melanoma	GDSC	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1111
p.P256L	ACH-000814	Skin Cancer	CCLE	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1111
p.P256L	Hs939-T	skin	COSMIC	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1111
p.S236C	TCGA-BH-A18M	BRCA	TCGA	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation blocking phosphorylation signal	0.5833
p.S236C	DO4245	BRCA	ICGC	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation blocking phosphorylation signal	0.5833
p.E238K	TCGA-D1-A17Q	UCEC	TCGA	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1944
p.E238K	DO41903	UCEC	ICGC	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1944
p.S242G	DO234318	ESAD	ICGC	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation blocking phosphorylation signal	0.75
p.H258Y	SIDM00217	Colorectal Carcinoma	GDSC	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.0556
p.H258Y	ACH-000999	Colon/Colorectal Cancer	CCLE	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.0556
p.H258Y	SNU-1040	large intestine	COSMIC	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.0556
p.G237E	ACH-000328	Brain Cancer	CCLE	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation rewiring degron network	0.1667
p.S242R	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTPKRS	DEG_SCF_FBW7_1	243:248	Mutation blocking phosphorylation signal	0.75

Kaplan plot for LIG3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIG3

UniProt ID: P49916

Entrez ID: 3980

Protein name: DNA ligase 3 (EC 6.5.1.1) (DNA ligase III) (Polydeoxyribonucleotide synthase [ATP] 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LIG3 in