DegronMD

Uniprot ID: P49916

Source protein: DNA ligase 3

Source gene: LIG3

Class: DEG_SCF_FBW7_1

Location: 243:248

E3 ligase: FBXW7

DEGRON score: 0.7566

ASA_SCORE: 96.85

COIL: 0.9145

CONS_SCORE: 0.2239

DSS_SCORE: 0.6352

HELIX: 0.0438

FCONS_SCORE: 0.7762

RIG_SCORE: 0.5717

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P256L	TCGA-AZ-6598	COAD	TCGA	PTPKRS	DEG_SCF_FBW7_1	0.1111
p.P256L	DO10276	COAD	ICGC	PTPKRS	DEG_SCF_FBW7_1	0.1111
p.P256L	SIDM00663	Melanoma	GDSC	PTPKRS	DEG_SCF_FBW7_1	0.1111
p.P256L	ACH-000814	Skin Cancer	CCLE	PTPKRS	DEG_SCF_FBW7_1	0.1111
p.P256L	Hs939-T	skin	COSMIC	PTPKRS	DEG_SCF_FBW7_1	0.1111
p.S236C	TCGA-BH-A18M	BRCA	TCGA	PTPKRS	DEG_SCF_FBW7_1	0.5833
p.S236C	DO4245	BRCA	ICGC	PTPKRS	DEG_SCF_FBW7_1	0.5833
p.E238K	TCGA-D1-A17Q	UCEC	TCGA	PTPKRS	DEG_SCF_FBW7_1	0.1944
p.E238K	DO41903	UCEC	ICGC	PTPKRS	DEG_SCF_FBW7_1	0.1944
p.S242G	DO234318	ESAD	ICGC	PTPKRS	DEG_SCF_FBW7_1	0.75
p.H258Y	SIDM00217	Colorectal Carcinoma	GDSC	PTPKRS	DEG_SCF_FBW7_1	0.0556
p.H258Y	ACH-000999	Colon/Colorectal Cancer	CCLE	PTPKRS	DEG_SCF_FBW7_1	0.0556
p.H258Y	SNU-1040	large_intestine	COSMIC	PTPKRS	DEG_SCF_FBW7_1	0.0556
p.G237E	ACH-000328	Brain Cancer	CCLE	PTPKRS	DEG_SCF_FBW7_1	0.1667
p.S242R	ACH-000941	Endometrial/Uterine Cancer	CCLE	PTPKRS	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49916	DNA ligase 3	DEG_SCF_FBW7_1	243:248	PTPKRS	FBXW7	0.7566	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons