DegronMD - P50452(SERPINB8)

FUNCTION: Has an important role in epithelial desmosome-mediated cell-cell adhesion. {ECO:0000269|PubMed:27476651}.

GO - Biological processes (BP): epithelial cell-cell adhesion [GO:0090136]; negative regulation of endopeptidase activity [GO:0010951]

GO - Molecular function (MF): serine-type endopeptidase inhibitor activity [GO:0004867]

GO - Cellular component (CC): collagen-containing extracellular matrix [GO:0062023]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; extracellular exosome [GO:0070062]; extracellular space [GO:0005615]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E60K	EFO-21	ovary	COSMIC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7022
p.P50L	DO37406	SKCM	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation blocking phosphorylation signal	0.5556
p.P50S	MDST8	large intestine	COSMIC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation blocking phosphorylation signal	0.5556
p.G64E	TCGA-G2-A2EO	BLCA	TCGA	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.3056
p.G64E	DO456	BLCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.3056
p.A57T	DO41758	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.3056
p.D65Y	TCGA-EY-A215	UCEC	TCGA	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.D65Y	DO42665	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.I66T	SIDM00994	T-Lymphoblastic Leukemia	GDSC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.25
p.I66T	SIDM01746	Osteosarcoma	GDSC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.25
p.I66T	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.25
p.H67P	TCGA-FU-A3HZ	CESC	TCGA	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.H67P	DO6308	CESC	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.M54L	TCGA-NK-A5D1	LUSC	TCGA	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.M54L	DO219213	LUSC	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.M54I	DO225346	BRCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.M54I	DO229022	LICA	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.R68Q	DO230334	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1944
p.R68Q	DO229016	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1944
p.R68Q	DO229003	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 34 entries

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Kaplan plot for SERPINB8 in

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

SERPINB8

UniProt ID: P50452

Entrez ID: 5271

Protein name: Serpin B8 (Cytoplasmic antiproteinase 2) (CAP-2) (CAP2) (Peptidase inhibitor 8) (PI-8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SERPINB8 in