DegronMD

Uniprot ID: P50452

Source protein: Serpin B8

Source gene: SERPINB8

Class: LIG_APCC_ABBA_1

Location: 58:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.566

ASA_SCORE: 81.0167

COIL: 0.8265

CONS_SCORE: 0.3516

DSS_SCORE: 0.1386

HELIX: 0.1675

FCONS_SCORE: 0.8238

RIG_SCORE: 0.8576

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A51V	TCGA-AP-A059	UCEC	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.1389
p.A51V	DO41361	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1389
p.G69C	TCGA-DF-A2KU	UCEC	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.1667
p.S72L	TCGA-DK-A1AC	BLCA	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.0833
p.S72L	DO514	BLCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.0833
p.D65Y	TCGA-EY-A215	UCEC	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.2778
p.D65Y	DO42665	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2778
p.H67P	TCGA-FU-A3HZ	CESC	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.H67P	DO6308	CESC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.G64E	TCGA-G2-A2EO	BLCA	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.3056
p.G64E	DO456	BLCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.3056
p.M54L	TCGA-NK-A5D1	LUSC	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.M54L	DO219213	LUSC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.M54I	DO225346	BRCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.M54I	DO229022	LICA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.R68Q	DO230334	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO229016	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO229003	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO230659	LAML	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO231140	LAML	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO228947	LICA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO230979	LUSC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.S49N	DO220902	MELA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.0833
p.P50L	DO37406	SKCM	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.5556
p.A57T	DO41758	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.3056
p.F68V	DO41542	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.I66T	SIDM00994	T-Lymphoblastic Leukemia	GDSC	LCLYKD	LIG_APCC_ABBA_1	0.25
p.I66T	SIDM01746	Osteosarcoma	GDSC	LCLYKD	LIG_APCC_ABBA_1	0.25
p.I66T	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	LCLYKD	LIG_APCC_ABBA_1	0.25
p.A52V	SIDM00516	Melanoma	GDSC	LCLYKD	LIG_APCC_ABBA_1	0.1667
p.A52V	ACH-002166	Skin Cancer	CCLE	LCLYKD	LIG_APCC_ABBA_1	0.1667
p.A52V	MZ7-mel	skin	COSMIC	LCLYKD	LIG_APCC_ABBA_1	0.1667
p.E60K	EFO-21	ovary	COSMIC	LCLYKD	LIG_APCC_ABBA_1	0.7022
p.P50S	MDST8	large_intestine	COSMIC	LCLYKD	LIG_APCC_ABBA_1	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LCLYKD

Degron related mutations and impact score

Drug responses associated with SERPINB8 mutations

All proteins holding degron of LCLYKD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50452	Serpin B8	LIG_APCC_ABBA_1	58:63	LCLYKD	APC,CDC20,FZR1	0.566	More...