DegronMD

Uniprot ID: P50452

Source protein: Serpin B8

Source gene: SERPINB8

Class: LIG_APCC_ABBA_1

Location: 58:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.566

ASA_SCORE: 81.0167

COIL: 0.8265

CONS_SCORE: 0.3516

DSS_SCORE: 0.1386

HELIX: 0.1675

FCONS_SCORE: 0.8238

RIG_SCORE: 0.8576

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E60K	EFO-21	ovary	COSMIC	LCLYKD	LIG_APCC_ABBA_1	0.7022
p.P50L	DO37406	SKCM	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.5556
p.P50S	MDST8	large_intestine	COSMIC	LCLYKD	LIG_APCC_ABBA_1	0.5556
p.G64E	TCGA-G2-A2EO	BLCA	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.3056
p.G64E	DO456	BLCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.3056
p.A57T	DO41758	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.3056
p.D65Y	TCGA-EY-A215	UCEC	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.2778
p.D65Y	DO42665	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2778
p.I66T	SIDM00994	T-Lymphoblastic Leukemia	GDSC	LCLYKD	LIG_APCC_ABBA_1	0.25
p.I66T	SIDM01746	Osteosarcoma	GDSC	LCLYKD	LIG_APCC_ABBA_1	0.25
p.I66T	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	LCLYKD	LIG_APCC_ABBA_1	0.25
p.H67P	TCGA-FU-A3HZ	CESC	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.H67P	DO6308	CESC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.M54L	TCGA-NK-A5D1	LUSC	TCGA	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.M54L	DO219213	LUSC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.M54I	DO225346	BRCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.M54I	DO229022	LICA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.2222
p.R68Q	DO230334	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO229016	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO229003	COCA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO230659	LAML	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO231140	LAML	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO228947	LICA	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.R68Q	DO230979	LUSC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944
p.F68V	DO41542	UCEC	ICGC	LCLYKD	LIG_APCC_ABBA_1	0.1944

Showing 1 to 25 of 34 entries

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50452	Serpin B8	LIG_APCC_ABBA_1	58:63	LCLYKD	APC,CDC20,FZR1	0.566	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons