DegronMD - P50552(VASP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T335A	TCGA-06-2564	GBM	TCGA	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation altering degron motif	0.825
p.T335A	DO13378	GBM	ICGC	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation altering degron motif	0.825
p.Q345H	TCGA-17-Z020	LUAD	TCGA	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation rewiring degron network	0.1667
p.E330K	TCGA-AO-A128	BRCA	TCGA	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation rewiring degron network	0.25
p.E330K	DO5326	BRCA	ICGC	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation rewiring degron network	0.25
p.T331A	DO8264	COAD	ICGC	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation blocking phosphorylation signal	0.7222
p.C334F	DO229034	LICA	ICGC	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation altering degron motif	0.5996
p.S324C	SIDM00516	Melanoma	GDSC	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation blocking phosphorylation signal	0.5278
p.S324C	SIDM01879	Non-Cancerous	GDSC	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation blocking phosphorylation signal	0.5278
p.S324C	ACH-002361	Non-Cancerous	CCLE	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation blocking phosphorylation signal	0.5278
p.T335M	22RV1	prostate	COSMIC	PCTPSSS	DEG_SCF_FBW7_1	333:339	Mutation altering degron motif	0.8534

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons