DegronMD

Uniprot ID: P50552

Source protein: Vasodilator-stimulated phosphoprotein

Source gene: VASP

Class: DEG_SCF_FBW7_1

Location: 333:339

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 81.5143

COIL: 0.9277

CONS_SCORE: 0.3768

DSS_SCORE: 0.6044

HELIX: 0.0514

FCONS_SCORE: 0.9866

RIG_SCORE: 0.6145

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T335A	TCGA-06-2564	GBM	TCGA	PCTPSSS	DEG_SCF_FBW7_1	0.825
p.T335A	DO13378	GBM	ICGC	PCTPSSS	DEG_SCF_FBW7_1	0.825
p.Q345H	TCGA-17-Z020	LUAD	TCGA	PCTPSSS	DEG_SCF_FBW7_1	0.1667
p.E330K	TCGA-AO-A128	BRCA	TCGA	PCTPSSS	DEG_SCF_FBW7_1	0.25
p.E330K	DO5326	BRCA	ICGC	PCTPSSS	DEG_SCF_FBW7_1	0.25
p.T331A	DO8264	COAD	ICGC	PCTPSSS	DEG_SCF_FBW7_1	0.7222
p.C334F	DO229034	LICA	ICGC	PCTPSSS	DEG_SCF_FBW7_1	0.5996
p.S324C	SIDM00516	Melanoma	GDSC	PCTPSSS	DEG_SCF_FBW7_1	0.5278
p.S324C	SIDM01879	Non-Cancerous	GDSC	PCTPSSS	DEG_SCF_FBW7_1	0.5278
p.S324C	ACH-002361	Non-Cancerous	CCLE	PCTPSSS	DEG_SCF_FBW7_1	0.5278
p.T335M	22RV1	prostate	COSMIC	PCTPSSS	DEG_SCF_FBW7_1	0.8534

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50552	Vasodilator-stimulated phosphoprotein	DEG_SCF_FBW7_1	333:339	PCTPSSS	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons