DegronMD - P51116(FXR2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R286Q	TCGA-AX-A2HC	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0833
p.R286Q	DO41572	UCEC	ICGC	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0833
p.I263V	TCGA-B6-A0I1	BRCA	TCGA	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0833
p.I263V	DO4138	BRCA	ICGC	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.0833
p.R273S	TCGA-D3-A2JO	SKCM	TCGA	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation altering degron motif	0.6316
p.R273S	DO47619	SKCM	ICGC	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation altering degron motif	0.6316
p.R273H	DO222946	BTCA	ICGC	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation altering degron motif	0.7133
p.R273H	DO232761	PBCA	ICGC	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation altering degron motif	0.7133
p.G266R	ACH-001799	Liposarcoma	CCLE	FRIYGE	LIG_APCC_ABBA_1	272:277	Mutation rewiring degron network	0.1667

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons