DegronMD

Uniprot ID: P51116

Source protein: Fragile X mental retardation syndrome-related protein 2

Source gene: FXR2

Class: LIG_APCC_ABBA_1

Location: 272:277

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.817

ASA_SCORE: 49.0167

COIL: 0.2865

CONS_SCORE: 0.5659

DSS_SCORE: 0.2768

HELIX: 0.002

FCONS_SCORE: 0.8795

RIG_SCORE: 0.8496

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R286Q	TCGA-AX-A2HC	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.0833
p.R286Q	DO41572	UCEC	ICGC	FRIYGE	LIG_APCC_ABBA_1	0.0833
p.I263V	TCGA-B6-A0I1	BRCA	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.0833
p.I263V	DO4138	BRCA	ICGC	FRIYGE	LIG_APCC_ABBA_1	0.0833
p.R273S	TCGA-D3-A2JO	SKCM	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.6316
p.R273S	DO47619	SKCM	ICGC	FRIYGE	LIG_APCC_ABBA_1	0.6316
p.R273H	DO222946	BTCA	ICGC	FRIYGE	LIG_APCC_ABBA_1	0.7133
p.R273H	DO232761	PBCA	ICGC	FRIYGE	LIG_APCC_ABBA_1	0.7133
p.G266R	ACH-001799	Liposarcoma	CCLE	FRIYGE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51114	Fragile X mental retardation syndrome-related protein 1	LIG_APCC_ABBA_1	262:267	FRIYGE	APC,CDC20,FZR1	0.562	More...
P51116	Fragile X mental retardation syndrome-related protein 2	LIG_APCC_ABBA_1	272:277	FRIYGE	APC,CDC20,FZR1	0.817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons