DegronMD

Uniprot ID: P51114

Source protein: Fragile X mental retardation syndrome-related protein 1

Source gene: FXR1

Class: LIG_APCC_ABBA_1

Location: 262:267

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.562

ASA_SCORE: 53.7833

COIL: 0.2775

CONS_SCORE: 0.5643

DSS_SCORE: 0.2667

HELIX: 0.0033

FCONS_SCORE: 0.912

RIG_SCORE: 0.8352

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A252T	TCGA-2W-A8YY	CESC	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.0556
p.A252T	TCGA-AX-A2HC	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.0556
p.A271D	TCGA-A5-A1OF	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.2222
p.G277S	TCGA-AP-A051	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.0556
p.G277S	TCGA-EO-A22U	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.0556
p.F262L	TCGA-AR-A0U0	BRCA	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.587
p.K273Q	TCGA-AX-A0J0	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	0.6111
p.A252V	DO234350	ESAD	ICGC	FRIYGE	LIG_APCC_ABBA_1	0.0556
p.A275D	DO229232	THCA	ICGC	FRIYGE	LIG_APCC_ABBA_1	0.1111
p.R276G	SIDM00965	Small Cell Lung Carcinoma	GDSC	FRIYGE	LIG_APCC_ABBA_1	0.0833
p.R276G	ACH-000800	Lung Cancer	CCLE	FRIYGE	LIG_APCC_ABBA_1	0.0833
p.R276G	NCI-H446	lung	COSMIC	FRIYGE	LIG_APCC_ABBA_1	0.0833
p.Q263R	MFE-319	endometrium	COSMIC	FRIYGE	LIG_APCC_ABBA_1	0.7329
p.R263G	NCI-H446	lung	COSMIC	FRIYGE	LIG_APCC_ABBA_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51114	Fragile X mental retardation syndrome-related protein 1	LIG_APCC_ABBA_1	262:267	FRIYGE	APC,CDC20,FZR1	0.562	More...
P51116	Fragile X mental retardation syndrome-related protein 2	LIG_APCC_ABBA_1	272:277	FRIYGE	APC,CDC20,FZR1	0.817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons