DegronMD - P51114(FXR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A252T	TCGA-2W-A8YY	CESC	TCGA	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.A252T	TCGA-AX-A2HC	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.D589N	TCGA-2W-A8YY	CESC	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1944
p.D589N	SIDM01180	Hepatocellular Carcinoma	GDSC	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1944
p.D589N	ACH-000478	Liver Cancer	CCLE	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1944
p.D589N	SNU-387	liver	COSMIC	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1944
p.T584I	TCGA-A5-A0G2	UCEC	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.0556
p.A271D	TCGA-A5-A1OF	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.2222
p.G277S	TCGA-AP-A051	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.G277S	TCGA-EO-A22U	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.F262L	TCGA-AR-A0U0	BRCA	TCGA	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.587
p.D589G	TCGA-AX-A063	UCEC	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1944
p.K273Q	TCGA-AX-A0J0	UCEC	TCGA	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation blocking ubiquitination signal	0.6111
p.I603S	TCGA-B5-A3FA	UCEC	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.2778
p.N604D	TCGA-F4-6570	COAD	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.25
p.N604D	DO10443	COAD	ICGC	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.25
p.A586V	TCGA-RE-A7BO	ESCA	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1111
p.A252V	DO234350	ESAD	ICGC	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0556
p.A275D	DO229232	THCA	ICGC	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.1111
p.G588C	SIDM00829	Acute Myeloid Leukemia	GDSC	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1667
p.G588C	ACH-000002	Leukemia	CCLE	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1667
p.G588C	HL-60	haematopoietic and lymphoid tissue	COSMIC	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation rewiring degron network	0.1667
p.R276G	SIDM00965	Small Cell Lung Carcinoma	GDSC	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0833
p.R276G	ACH-000800	Lung Cancer	CCLE	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0833
p.R276G	NCI-H446	lung	COSMIC	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation rewiring degron network	0.0833
p.P598S	SIDM01045	Endometrial Carcinoma	GDSC	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation altering degron motif	0.6752
p.P598S	ACH-000978	Endometrial/Uterine Cancer	CCLE	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation altering degron motif	0.6752
p.P598S	EN	endometrium	COSMIC	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation altering degron motif	0.6752
p.Q263R	MFE-319	endometrium	COSMIC	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.7329
p.P585S	EN	endometrium	COSMIC	LQRTPGEE	DEG_SCF_FBW7_2	594:601	Mutation blocking phosphorylation signal	0.5278
p.R263G	NCI-H446	lung	COSMIC	FRIYGE	LIG_APCC_ABBA_1	262:267	Mutation altering degron motif	0.6457

Kaplan plot for FXR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FXR1

UniProt ID: P51114

Entrez ID: 8087

Protein name: Fragile X mental retardation syndrome-related protein 1 (hFXR1p)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FXR1 in