DegronMD

Uniprot ID: P51114

Source protein: Fragile X mental retardation syndrome-related protein 1

Source gene: FXR1

Class: DEG_SCF_FBW7_2

Location: 594:601

E3 ligase: FBXW7

DEGRON score: 0.9374

ASA_SCORE: 104.2125

COIL: 0.7813

CONS_SCORE: 0.3147

DSS_SCORE: 0.6159

HELIX: 0.2093

FCONS_SCORE: 0.9138

RIG_SCORE: 0.6774

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D589N	TCGA-2W-A8YY	CESC	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	0.1944
p.D589N	SIDM01180	Hepatocellular Carcinoma	GDSC	LQRTPGEE	DEG_SCF_FBW7_2	0.1944
p.D589N	ACH-000478	Liver Cancer	CCLE	LQRTPGEE	DEG_SCF_FBW7_2	0.1944
p.D589N	SNU-387	liver	COSMIC	LQRTPGEE	DEG_SCF_FBW7_2	0.1944
p.T584I	TCGA-A5-A0G2	UCEC	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	0.0556
p.D589G	TCGA-AX-A063	UCEC	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	0.1944
p.I603S	TCGA-B5-A3FA	UCEC	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	0.2778
p.N604D	TCGA-F4-6570	COAD	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	0.25
p.N604D	DO10443	COAD	ICGC	LQRTPGEE	DEG_SCF_FBW7_2	0.25
p.A586V	TCGA-RE-A7BO	ESCA	TCGA	LQRTPGEE	DEG_SCF_FBW7_2	0.1111
p.G588C	SIDM00829	Acute Myeloid Leukemia	GDSC	LQRTPGEE	DEG_SCF_FBW7_2	0.1667
p.G588C	ACH-000002	Leukemia	CCLE	LQRTPGEE	DEG_SCF_FBW7_2	0.1667
p.G588C	HL-60	haematopoietic_and_lymphoid_tissue	COSMIC	LQRTPGEE	DEG_SCF_FBW7_2	0.1667
p.P598S	SIDM01045	Endometrial Carcinoma	GDSC	LQRTPGEE	DEG_SCF_FBW7_2	0.6752
p.P598S	ACH-000978	Endometrial/Uterine Cancer	CCLE	LQRTPGEE	DEG_SCF_FBW7_2	0.6752
p.P598S	EN	endometrium	COSMIC	LQRTPGEE	DEG_SCF_FBW7_2	0.6752
p.P585S	EN	endometrium	COSMIC	LQRTPGEE	DEG_SCF_FBW7_2	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51114	Fragile X mental retardation syndrome-related protein 1	DEG_SCF_FBW7_2	594:601	LQRTPGEE	FBXW7	0.9374	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons