DegronMD - P51149(RAB7A)

FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Required for vesicular trafficking and cell surface expression of ACE2 (PubMed:33147445). May play a role in PRPH neuronal intermediate filament assembly (By similarity). {ECO:0000250|UniProtKB:P51150, ECO:0000269|PubMed:11179213, ECO:0000269|PubMed:12944476, ECO:0000269|PubMed:14617358, ECO:0000269|PubMed:20028791, ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:33147445}. View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E185K	TCGA-B5-A11E	UCEC	TCGA	VELYNE	LIG_APCC_ABBA_1	180:185	Mutation altering degron motif	0.7022
p.E185K	TCGA-EI-6917	READ	TCGA	VELYNE	LIG_APCC_ABBA_1	180:185	Mutation altering degron motif	0.7022
p.E185K	DO36881	READ	ICGC	VELYNE	LIG_APCC_ABBA_1	180:185	Mutation altering degron motif	0.7022
p.E185K	DO41644	UCEC	ICGC	VELYNE	LIG_APCC_ABBA_1	180:185	Mutation altering degron motif	0.7022
p.I190V	DO222874	COCA	ICGC	VELYNE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.1944
p.T178M	DO234199	ESAD	ICGC	VELYNE	LIG_APCC_ABBA_1	180:185	Mutation blocking phosphorylation signal	0.7222
p.E179D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VELYNE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.3056
p.E179D	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VELYNE	LIG_APCC_ABBA_1	180:185	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RAB7A

UniProt ID: P51149

Entrez ID: 7879

Protein name: Ras-related protein Rab-7a (EC 3.6.5.2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RAB7A in