DegronMD

Uniprot ID: P51149

Source protein: Ras-related protein Rab-7a

Source gene: RAB7A

Class: LIG_APCC_ABBA_1

Location: 180:185

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8807

ASA_SCORE: 97.05

COIL: 0.5318

CONS_SCORE: 0.3721

DSS_SCORE: 0.3729

HELIX: 0.4445

FCONS_SCORE: 0.7213

RIG_SCORE: 0.826

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E185K	TCGA-B5-A11E	UCEC	TCGA	VELYNE	LIG_APCC_ABBA_1	0.7022
p.E185K	TCGA-EI-6917	READ	TCGA	VELYNE	LIG_APCC_ABBA_1	0.7022
p.E185K	DO36881	READ	ICGC	VELYNE	LIG_APCC_ABBA_1	0.7022
p.E185K	DO41644	UCEC	ICGC	VELYNE	LIG_APCC_ABBA_1	0.7022
p.I190V	DO222874	COCA	ICGC	VELYNE	LIG_APCC_ABBA_1	0.1944
p.T178M	DO234199	ESAD	ICGC	VELYNE	LIG_APCC_ABBA_1	0.7222
p.E179D	SIDM01007	T-Lymphoblastic Leukemia	GDSC	VELYNE	LIG_APCC_ABBA_1	0.3056
p.E179D	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VELYNE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51149	Ras-related protein Rab-7a	LIG_APCC_ABBA_1	180:185	VELYNE	APC,CDC20,FZR1	0.8807	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons