DegronMD - P51451(BLK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R222C	TCGA-06-5416	GBM	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.719
p.L218V	TCGA-38-4625	LUAD	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.6765
p.R222P	TCGA-78-7147	LUAD	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.6401
p.H204Y	TCGA-AA-3672	COAD	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.0556
p.Q231H	TCGA-AA-3949	COAD	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.0833
p.Q231H	DO7798	COAD	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.0833
p.A230V	TCGA-AX-A05Z	UCEC	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1111
p.E213Q	DO51933	BLCA	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.3056
p.E223A	DO10582	COAD	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.3056
p.R227Q	DO222448	ESCA	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1944
p.P207A	DO26740	LUSC	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation substituting flanking lysine	0.25
p.S206Y	DO233297	NACA	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1111
p.A214V	DO232224	PBCA	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.6936
p.R224L	DO51251	SKCM	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.2778
p.P223L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.3056
p.P223L	ACH-002211	Leukemia	CCLE	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.3056
p.P223L	BALL-1	haematopoietic and lymphoid tissue	COSMIC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.3056
p.A230T	SNU-1040	large intestine	COSMIC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation rewiring degron network	0.1111
p.N215K	BT-20	breast	COSMIC	QRLTLPCVR	DEG_APCC_DBOX_1	214:222	Mutation altering degron motif	0.6918

Kaplan plot for BLK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BLK

UniProt ID: P51451

Entrez ID: 640

Protein name: Tyrosine-protein kinase Blk (EC 2.7.10.2) (B lymphocyte kinase) (p55-Blk)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BLK in