DegronMD

Uniprot ID: P51451

Source protein: Tyrosine-protein kinase Blk

Source gene: BLK

Class: DEG_APCC_DBOX_1

Location: 214:222

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6005

ASA_SCORE: 56.6

COIL: 0.5968

CONS_SCORE: 0.5071

DSS_SCORE: 0.2999

HELIX: 0.0387

FCONS_SCORE: 0.8286

RIG_SCORE: 0.8155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R222C	TCGA-06-5416	GBM	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	0.719
p.L218V	TCGA-38-4625	LUAD	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	0.6765
p.R222P	TCGA-78-7147	LUAD	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	0.6401
p.H204Y	TCGA-AA-3672	COAD	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	0.0556
p.Q231H	TCGA-AA-3949	COAD	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	0.0833
p.Q231H	DO7798	COAD	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	0.0833
p.A230V	TCGA-AX-A05Z	UCEC	TCGA	QRLTLPCVR	DEG_APCC_DBOX_1	0.1111
p.E213Q	DO51933	BLCA	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	0.3056
p.E223A	DO10582	COAD	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	0.3056
p.R227Q	DO222448	ESCA	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	0.1944
p.P207A	DO26740	LUSC	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	0.25
p.S206Y	DO233297	NACA	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	0.1111
p.A214V	DO232224	PBCA	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	0.6936
p.R224L	DO51251	SKCM	ICGC	QRLTLPCVR	DEG_APCC_DBOX_1	0.2778
p.P223L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	QRLTLPCVR	DEG_APCC_DBOX_1	0.3056
p.P223L	ACH-002211	Leukemia	CCLE	QRLTLPCVR	DEG_APCC_DBOX_1	0.3056
p.P223L	BALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	QRLTLPCVR	DEG_APCC_DBOX_1	0.3056
p.A230T	SNU-1040	large_intestine	COSMIC	QRLTLPCVR	DEG_APCC_DBOX_1	0.1111
p.N215K	BT-20	breast	COSMIC	QRLTLPCVR	DEG_APCC_DBOX_1	0.6918

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51451	Tyrosine-protein kinase Blk	DEG_APCC_DBOX_1	214:222	QRLTLPCVR	APC,CDC20,FZR1	0.6005	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons