DegronMD - P51460(INSL3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E54K	TCGA-AA-3510	COAD	TCGA	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0833
p.E54K	TCGA-AA-3984	COAD	TCGA	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0833
p.E54K	DO9002	COAD	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0833
p.E54K	DO7783	COAD	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.0833
p.Q64K	TCGA-JW-AAVH	CESC	TCGA	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6944
p.Q64K	DO51605	CESC	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.6944
p.T60A	DO229010	COCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.T60A	DO229016	COCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.T60A	DO229003	COCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.T60A	DO229005	COCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.T60A	DO229489	LAML	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.T60A	DO229031	LICA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.25
p.G61A	DO50342	ESAD	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2778
p.H68Q	DO234365	ESAD	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.7582
p.H77N	DO229008	LICA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.A59V	DO23132	LINC	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.A59V	DO229250	THCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.2222
p.G62D	DO218900	SKCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.3056
p.H77Y	DO42256	UCEC	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1667
p.E71D	ACH-000473	Bladder Cancer	CCLE	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5647
p.E71D	ACH-001183	Bladder Cancer	CCLE	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation altering degron motif	0.5647
p.L79M	ACH-000596	Lung Cancer	CCLE	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111
p.L79M	LCLC-97TM1	lung	COSMIC	DRELLQWLE	DEG_APCC_DBOX_1	63:71	Mutation rewiring degron network	0.1111

Kaplan plot for INSL3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INSL3

UniProt ID: P51460

Entrez ID: 3640

Protein name: Insulin-like 3 (Leydig insulin-like peptide) (Ley-I-L) (Relaxin-like factor) [Cleaved into: Insulin-like 3 B chain; Insulin-like 3 A chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INSL3 in