DegronMD

Uniprot ID: P51460

Source protein: Insulin-like 3

Source gene: INSL3

Class: DEG_APCC_DBOX_1

Location: 63:71

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7534

ASA_SCORE: 83.2667

COIL: 0.2384

CONS_SCORE: 0.8993

DSS_SCORE: 0.3052

HELIX: 0.7569

FCONS_SCORE: 1.2898

RIG_SCORE: 0.8394

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H68Q	DO234365	ESAD	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.7582
p.Q64K	TCGA-JW-AAVH	CESC	TCGA	DRELLQWLE	DEG_APCC_DBOX_1	0.6944
p.Q64K	DO51605	CESC	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.6944
p.E71D	ACH-000473	Bladder Cancer	CCLE	DRELLQWLE	DEG_APCC_DBOX_1	0.5647
p.E71D	ACH-001183	Bladder Cancer	CCLE	DRELLQWLE	DEG_APCC_DBOX_1	0.5647
p.G62D	DO218900	SKCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.3056
p.G61A	DO50342	ESAD	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.2778
p.T60A	DO229010	COCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.25
p.T60A	DO229016	COCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.25
p.T60A	DO229003	COCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.25
p.T60A	DO229005	COCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.25
p.T60A	DO229489	LAML	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.25
p.T60A	DO229031	LICA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.25
p.A59V	DO23132	LINC	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.2222
p.A59V	DO229250	THCA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.2222
p.H77N	DO229008	LICA	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.1667
p.H77Y	DO42256	UCEC	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.1667
p.L79M	ACH-000596	Lung Cancer	CCLE	DRELLQWLE	DEG_APCC_DBOX_1	0.1111
p.L79M	LCLC-97TM1	lung	COSMIC	DRELLQWLE	DEG_APCC_DBOX_1	0.1111
p.E54K	TCGA-AA-3510	COAD	TCGA	DRELLQWLE	DEG_APCC_DBOX_1	0.0833
p.E54K	TCGA-AA-3984	COAD	TCGA	DRELLQWLE	DEG_APCC_DBOX_1	0.0833
p.E54K	DO9002	COAD	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.0833
p.E54K	DO7783	COAD	ICGC	DRELLQWLE	DEG_APCC_DBOX_1	0.0833

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51460	Insulin-like 3	DEG_APCC_DBOX_1	63:71	DRELLQWLE	APC,CDC20,FZR1	0.7534	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons