DegronMD - P51512(MMP16)

FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}.

GO - Biological processes (BP): chondrocyte proliferation [GO:0035988]; collagen catabolic process [GO:0030574]; craniofacial suture morphogenesis [GO:0097094]; embryonic cranial skeleton morphogenesis [GO:0048701]; endochondral ossification [GO:0001958]; extracellular matrix organization [GO:0030198]; protein processing [GO:00164... View more >>

GO - Molecular function (MF): enzyme activator activity [GO:0008047]; metalloaminopeptidase activity [GO:0070006]; metalloendopeptidase activity [GO:0004222]; zinc ion binding [GO:0008270]

GO - Cellular component (CC): cell surface [GO:0009986]; extracellular matrix [GO:0031012]; extracellular region [GO:0005576]; Golgi lumen [GO:0005796]; integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q363H	TCGA-18-3410	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.Q363H	DO26456	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.Q363H	SIDM01205	Acute Myeloid Leukemia	GDSC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.Q363H	ACH-002314	Leukemia	CCLE	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.Q363H	TUR	haematopoietic and lymphoid tissue	COSMIC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.F365I	TCGA-55-A492	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6304
p.F365I	DO23708	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6304
p.R367Q	TCGA-A5-A0G2	UCEC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6218
p.R367Q	TCGA-L5-A43E	ESCA	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6218
p.R367Q	DO222653	MELA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6218
p.R367Q	DO41235	UCEC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6218
p.F365C	DO233944	GACA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.5996
p.V359L	TCGA-22-5481	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.V359L	DO27160	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.R369K	TCGA-A5-A2K5	UCEC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.R369K	DO41379	UCEC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.V359A	TCGA-AA-3811	COAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.V359A	DO7962	COAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.R369T	TCGA-E2-A10C	BRCA	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.R369T	DO1334	BRCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 70 entries

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Kaplan plot for MMP16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MMP16

UniProt ID: P51512

Entrez ID: 4325

Protein name: Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MMP16 in