DegronMD - P51512(MMP16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q363H	TCGA-18-3410	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.Q363H	DO26456	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.Q363H	SIDM01205	Acute Myeloid Leukemia	GDSC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.Q363H	ACH-002314	Leukemia	CCLE	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.Q363H	TUR	haematopoietic and lymphoid tissue	COSMIC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.647
p.V359L	TCGA-22-5481	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.V359L	DO27160	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.P378S	TCGA-49-6743	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556
p.P378S	DO26092	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556
p.P378S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556
p.P378S	ACH-000647	Esophageal Cancer	CCLE	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556
p.P378S	TE-1	oesophagus	COSMIC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556
p.F365I	TCGA-55-A492	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6304
p.F365I	DO23708	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6304
p.M357T	TCGA-56-6546	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.25
p.M357T	DO26542	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.25
p.L353R	TCGA-56-7222	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.L353R	DO26842	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.L353R	SIDM02017	Colorectal Carcinoma	GDSC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.D375N	TCGA-60-2706	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.D375N	DO26914	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.G376V	TCGA-63-A5MV	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1111
p.G376V	DO219167	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1111
p.N370K	TCGA-73-4677	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.2778
p.N370K	DO23768	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.2778
p.V373L	TCGA-77-6843	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1944
p.V373L	DO27588	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1944
p.L350P	TCGA-94-A5I6	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556
p.L350P	DO219176	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556
p.G376R	TCGA-95-7039	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1111
p.G376R	DO23907	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1111
p.G376R	ACH-001111	Lymphoma	CCLE	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1111
p.D375Y	TCGA-99-8032	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.D375Y	DO224973	BRCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.D375Y	DO52555	BRCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.D375Y	DO23765	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.M374I	TCGA-99-8032	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.M374I	DO23765	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.R367Q	TCGA-A5-A0G2	UCEC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6218
p.R367Q	TCGA-L5-A43E	ESCA	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6218
p.R367Q	DO222653	MELA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6218
p.R367Q	DO41235	UCEC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.6218
p.R369K	TCGA-A5-A2K5	UCEC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.R369K	DO41379	UCEC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.V359A	TCGA-AA-3811	COAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.V359A	DO7962	COAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.R355C	TCGA-AJ-A3EL	UCEC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1944
p.R355C	DO41542	UCEC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1944
p.N370D	TCGA-BR-6452	STAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.2778
p.N370D	DO38404	STAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.2778
p.R354H	TCGA-CI-6622	READ	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.R354H	DO36435	READ	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.R369T	TCGA-E2-A10C	BRCA	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.R369T	DO1334	BRCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.3056
p.R354C	TCGA-FR-A726	SKCM	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.R354C	TCGA-HF-7132	STAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.R354C	DO230323	COCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.R354C	DO48665	SKCM	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.R354C	DO38214	STAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1667
p.L353I	TCGA-GS-A9TT	DLBC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.L353I	DO219912	DLBC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.L353I	DO228974	LICA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.N370I	TCGA-VQ-A8E0	STAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.2778
p.N370I	DO51757	STAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.2778
p.L353P	DO233817	GACA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.L353P	DO233822	GACA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1389
p.F365C	DO233944	GACA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation altering degron motif	0.5996
p.R355S	DO229045	LICA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.1944
p.P378Q	DO230965	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556
p.P378Q	DO224599	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	360:368	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MMP16

UniProt ID: P51512

Entrez ID: 4325

Protein name: Matrix metalloproteinase-16 (MMP-16) (EC 3.4.24.-) (MMP-X2) (Membrane-type matrix metalloproteinase 3) (MT-MMP 3) (MTMMP3) (Membrane-type-3 matrix metalloproteinase) (MT3-MMP) (MT3MMP)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MMP16 in