DegronMD

Uniprot ID: P51512

Source protein: Matrix metalloproteinase-16

Source gene: MMP16

Class: DEG_MDM2_SWIB_1

Location: 360:368

E3 ligase: MDM2

DEGRON score: 0.9191

ASA_SCORE: 51.3667

COIL: 0.2676

CONS_SCORE: 0.5009

DSS_SCORE: 0.035

HELIX: 0.0026

FCONS_SCORE: 1.3883

RIG_SCORE: 1.002

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q363H	TCGA-18-3410	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.647
p.Q363H	DO26456	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.647
p.Q363H	SIDM01205	Acute Myeloid Leukemia	GDSC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.647
p.Q363H	ACH-002314	Leukemia	CCLE	FKDQWFWRV	DEG_MDM2_SWIB_1	0.647
p.Q363H	TUR	haematopoietic_and_lymphoid_tissue	COSMIC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.647
p.V359L	TCGA-22-5481	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.3056
p.V359L	DO27160	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.3056
p.P378S	TCGA-49-6743	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556
p.P378S	DO26092	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556
p.P378S	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556
p.P378S	ACH-000647	Esophageal Cancer	CCLE	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556
p.P378S	TE-1	oesophagus	COSMIC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556
p.F365I	TCGA-55-A492	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.6304
p.F365I	DO23708	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.6304
p.M357T	TCGA-56-6546	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.25
p.M357T	DO26542	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.25
p.L353R	TCGA-56-7222	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.L353R	DO26842	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.L353R	SIDM02017	Colorectal Carcinoma	GDSC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.D375N	TCGA-60-2706	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.D375N	DO26914	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.G376V	TCGA-63-A5MV	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1111
p.G376V	DO219167	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1111
p.N370K	TCGA-73-4677	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.2778
p.N370K	DO23768	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.2778
p.V373L	TCGA-77-6843	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1944
p.V373L	DO27588	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1944
p.L350P	TCGA-94-A5I6	LUSC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556
p.L350P	DO219176	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556
p.G376R	TCGA-95-7039	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1111
p.G376R	DO23907	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1111
p.G376R	ACH-001111	Lymphoma	CCLE	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1111
p.D375Y	TCGA-99-8032	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.D375Y	DO224973	BRCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.D375Y	DO52555	BRCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.D375Y	DO23765	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.M374I	TCGA-99-8032	LUAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.M374I	DO23765	LUAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.R367Q	TCGA-A5-A0G2	UCEC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.6218
p.R367Q	TCGA-L5-A43E	ESCA	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.6218
p.R367Q	DO222653	MELA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.6218
p.R367Q	DO41235	UCEC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.6218
p.R369K	TCGA-A5-A2K5	UCEC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.3056
p.R369K	DO41379	UCEC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.3056
p.V359A	TCGA-AA-3811	COAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.3056
p.V359A	DO7962	COAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.3056
p.R355C	TCGA-AJ-A3EL	UCEC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1944
p.R355C	DO41542	UCEC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1944
p.N370D	TCGA-BR-6452	STAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.2778
p.N370D	DO38404	STAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.2778
p.R354H	TCGA-CI-6622	READ	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.R354H	DO36435	READ	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.R369T	TCGA-E2-A10C	BRCA	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.3056
p.R369T	DO1334	BRCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.3056
p.R354C	TCGA-FR-A726	SKCM	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.R354C	TCGA-HF-7132	STAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.R354C	DO230323	COCA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.R354C	DO48665	SKCM	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.R354C	DO38214	STAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1667
p.L353I	TCGA-GS-A9TT	DLBC	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.L353I	DO219912	DLBC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.L353I	DO228974	LICA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.N370I	TCGA-VQ-A8E0	STAD	TCGA	FKDQWFWRV	DEG_MDM2_SWIB_1	0.2778
p.N370I	DO51757	STAD	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.2778
p.L353P	DO233817	GACA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.L353P	DO233822	GACA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1389
p.F365C	DO233944	GACA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.5996
p.R355S	DO229045	LICA	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.1944
p.P378Q	DO230965	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556
p.P378Q	DO224599	LUSC	ICGC	FKDQWFWRV	DEG_MDM2_SWIB_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: FKDQWFWRV

Degron related mutations and impact score

Drug responses associated with MMP16 mutations

All proteins holding degron of FKDQWFWRV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51512	Matrix metalloproteinase-16	DEG_MDM2_SWIB_1	360:368	FKDQWFWRV	MDM2	0.9191	More...