DegronMD - P51513(NOVA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I177L	TCGA-50-6594	LUAD	TCGA	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.M166I	TCGA-AG-A002	READ	TCGA	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.6507
p.P155S	TCGA-EB-A431	SKCM	TCGA	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P155S	DO37671	SKCM	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P155S	639-V	urinary tract	COSMIC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.K159T	TCGA-HU-A4GU	STAD	TCGA	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2778
p.K159T	DO47849	STAD	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2778
p.A171D	TCGA-LT-A5Z6	BLCA	TCGA	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.A171D	DO44029	BLCA	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.A171D	DO229045	LICA	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.H177Y	DO225105	BRCA	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.K159R	DO234286	ESAD	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2778
p.N172T	DO234412	ESAD	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.25
p.Q173R	DO222292	GACA	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.L167S	DO233935	GACA	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7667
p.H175N	DO229028	LICA	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2778
p.I177V	DO23190	LINC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.H169Q	DO25471	LUAD	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7582
p.K159N	DO230971	LUSC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2778
p.K159N	DO224630	LUSC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2778
p.G168V	DO26468	LUSC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7532
p.A161S	DO219129	LUSC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation blocking phosphorylation signal	0.6667
p.I176V	DO49166	PACA	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.H177L	DO219952	SARC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.A177V	DO37471	SKCM	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1111
p.A163T	DO51267	SKCM	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2778
p.G168E	DO41211	UCEC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7199
p.N176S	DO42793	UCEC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389
p.L166I	DO42673	UCEC	ICGC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation altering degron motif	0.7174
p.S178F	SIDM00652	Small Cell Lung Carcinoma	GDSC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.S178F	ACH-000780	Lung Cancer	CCLE	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.S178F	NCI-H1105	lung	COSMIC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0833
p.P179S	SIDM00999	Bladder Carcinoma	GDSC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P179S	ACH-000973	Bladder Cancer	CCLE	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.P179S	639-V	urinary tract	COSMIC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.0556
p.V173I	Daudi	haematopoietic and lymphoid tissue	COSMIC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.V173I	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.V173I	DND-41	haematopoietic and lymphoid tissue	COSMIC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.2222
p.E175K	SNU-1040	large intestine	COSMIC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation substituting flanking lysine	0.2778
p.T158R	HCC1395	breast	COSMIC	PMTTS	DEG_SPOP_SBC_1	165:169	Mutation rewiring degron network	0.1389

Kaplan plot for NOVA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOVA1

UniProt ID: P51513

Entrez ID: 4857

Protein name: RNA-binding protein Nova-1 (Neuro-oncological ventral antigen 1) (Onconeural ventral antigen 1) (Paraneoplastic Ri antigen) (Ventral neuron-specific protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOVA1 in