DegronMD

Uniprot ID: P51513

Source protein: RNA-binding protein Nova-1

Source gene: NOVA1

Class: DEG_SPOP_SBC_1

Location: 165:169

E3 ligase: SPOP

DEGRON score: 0.8274

ASA_SCORE: 71.98

COIL: 0.7588

CONS_SCORE: 0.0882

DSS_SCORE: 0.6308

HELIX: 0.175

FCONS_SCORE: 0.4133

RIG_SCORE: 0.6721

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L167S	DO233935	GACA	ICGC	PMTTS	DEG_SPOP_SBC_1	0.7667
p.H169Q	DO25471	LUAD	ICGC	PMTTS	DEG_SPOP_SBC_1	0.7582
p.G168V	DO26468	LUSC	ICGC	PMTTS	DEG_SPOP_SBC_1	0.7532
p.G168E	DO41211	UCEC	ICGC	PMTTS	DEG_SPOP_SBC_1	0.7199
p.L166I	DO42673	UCEC	ICGC	PMTTS	DEG_SPOP_SBC_1	0.7174
p.A161S	DO219129	LUSC	ICGC	PMTTS	DEG_SPOP_SBC_1	0.6667
p.M166I	TCGA-AG-A002	READ	TCGA	PMTTS	DEG_SPOP_SBC_1	0.6507
p.K159T	TCGA-HU-A4GU	STAD	TCGA	PMTTS	DEG_SPOP_SBC_1	0.2778
p.K159T	DO47849	STAD	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.A171D	TCGA-LT-A5Z6	BLCA	TCGA	PMTTS	DEG_SPOP_SBC_1	0.2778
p.A171D	DO44029	BLCA	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.A171D	DO229045	LICA	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.K159R	DO234286	ESAD	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.H175N	DO229028	LICA	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.K159N	DO230971	LUSC	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.K159N	DO224630	LUSC	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.A163T	DO51267	SKCM	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.E175K	SNU-1040	large_intestine	COSMIC	PMTTS	DEG_SPOP_SBC_1	0.2778
p.N172T	DO234412	ESAD	ICGC	PMTTS	DEG_SPOP_SBC_1	0.25
p.Q173R	DO222292	GACA	ICGC	PMTTS	DEG_SPOP_SBC_1	0.2222
p.V173I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PMTTS	DEG_SPOP_SBC_1	0.2222
p.V173I	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PMTTS	DEG_SPOP_SBC_1	0.2222
p.V173I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PMTTS	DEG_SPOP_SBC_1	0.2222
p.I176V	DO49166	PACA	ICGC	PMTTS	DEG_SPOP_SBC_1	0.1389
p.N176S	DO42793	UCEC	ICGC	PMTTS	DEG_SPOP_SBC_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51513	RNA-binding protein Nova-1	DEG_SPOP_SBC_1	165:169	PMTTS	SPOP	0.8274	More...
Q5VU36	Spermatogenesis-associated protein 31A5	DEG_SPOP_SBC_1	173:177	PMTTS	SPOP	0.8057	More...
Q8IWB4	Spermatogenesis-associated protein 31A7	DEG_SPOP_SBC_1	173:177	PMTTS	SPOP	0.6834	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons