DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PMTTS
Uniprot ID:
Q5VU36
Source protein:
Spermatogenesis-associated protein 31A5
Source gene:
SPATA31A5
Class:
DEG_SPOP_SBC_1
Location:
173:177
E3 ligase:
SPOP
DEGRON score:
0.8057
ASA_SCORE:
86.82
COIL:
0.9108
CONS_SCORE:
0.3043
DSS_SCORE:
0.7496
HELIX:
0.0376
FCONS_SCORE:
0.8282
RIG_SCORE:
0.5374
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A166P
DO229272
THCA
ICGC
PMTTS
DEG_SPOP_SBC_1
0.1389
Drug responses associated with SPATA31A5 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PMTTS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P51513
RNA-binding protein Nova-1
DEG_SPOP_SBC_1
165:169
PMTTS
SPOP
0.8274
More...
Q8IWB4
Spermatogenesis-associated protein 31A7
DEG_SPOP_SBC_1
173:177
PMTTS
SPOP
0.6834
More...
Q5VU36
Spermatogenesis-associated protein 31A5
DEG_SPOP_SBC_1
173:177
PMTTS
SPOP
0.8057
More...