DegronMD - P51530(DNA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E110D	TCGA-49-4487	LUAD	TCGA	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.1389
p.A109T	TCGA-63-A5MY	LUSC	TCGA	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.1111
p.P108Q	TCGA-BR-4361	STAD	TCGA	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.0833
p.G128E	TCGA-XF-A9SI	BLCA	TCGA	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.1667
p.R132P	TCGA-XF-A9T3	BLCA	TCGA	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.0556
p.I110L	DO8264	COAD	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.1389
p.G127D	DO19058	KIRC	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.1944
p.T128N	DO228976	LICA	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.1667
p.D113G	DO45283	LIRI	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.2222
p.I110V	DO45129	LIRI	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.1389
p.P121S	DO222727	MELA	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation altering degron motif	0.5641
p.P121S	DO38028	SKCM	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation altering degron motif	0.5641
p.D113Y	DO232761	PBCA	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.2222
p.D113Y	DO41758	UCEC	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.2222
p.S129N	DO41361	UCEC	ICGC	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation rewiring degron network	0.1389
p.K112T	ACH-001991	Primary	CCLE	LILYPD	LIG_APCC_ABBA_1	117:122	Mutation substituting flanking lysine	0.3056

Kaplan plot for DNA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNA2

UniProt ID: P51530

Entrez ID: 1763

Protein name: DNA replication ATP-dependent helicase/nuclease DNA2 (hDNA2) (DNA replication ATP-dependent helicase-like homolog) [Includes: DNA replication nuclease DNA2 (EC 3.1.-.-); DNA replication ATP-dependent helicase DNA2 (EC 3.6.4.12)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNA2 in