DegronMD

Uniprot ID: P51530

Source protein: DNA replication ATP-dependent helicase/nuclease DNA2

Source gene: DNA2

Class: LIG_APCC_ABBA_1

Location: 117:122

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5095

ASA_SCORE: 12.9333

COIL: 0.4095

CONS_SCORE: 0.5351

DSS_SCORE: 0.0262

HELIX: 0.0093

FCONS_SCORE: 1.3137

RIG_SCORE: 0.989

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E110D	TCGA-49-4487	LUAD	TCGA	LILYPD	LIG_APCC_ABBA_1	0.1389
p.A109T	TCGA-63-A5MY	LUSC	TCGA	LILYPD	LIG_APCC_ABBA_1	0.1111
p.P108Q	TCGA-BR-4361	STAD	TCGA	LILYPD	LIG_APCC_ABBA_1	0.0833
p.G128E	TCGA-XF-A9SI	BLCA	TCGA	LILYPD	LIG_APCC_ABBA_1	0.1667
p.R132P	TCGA-XF-A9T3	BLCA	TCGA	LILYPD	LIG_APCC_ABBA_1	0.0556
p.I110L	DO8264	COAD	ICGC	LILYPD	LIG_APCC_ABBA_1	0.1389
p.G127D	DO19058	KIRC	ICGC	LILYPD	LIG_APCC_ABBA_1	0.1944
p.T128N	DO228976	LICA	ICGC	LILYPD	LIG_APCC_ABBA_1	0.1667
p.D113G	DO45283	LIRI	ICGC	LILYPD	LIG_APCC_ABBA_1	0.2222
p.I110V	DO45129	LIRI	ICGC	LILYPD	LIG_APCC_ABBA_1	0.1389
p.P121S	DO222727	MELA	ICGC	LILYPD	LIG_APCC_ABBA_1	0.5641
p.P121S	DO38028	SKCM	ICGC	LILYPD	LIG_APCC_ABBA_1	0.5641
p.D113Y	DO232761	PBCA	ICGC	LILYPD	LIG_APCC_ABBA_1	0.2222
p.D113Y	DO41758	UCEC	ICGC	LILYPD	LIG_APCC_ABBA_1	0.2222
p.S129N	DO41361	UCEC	ICGC	LILYPD	LIG_APCC_ABBA_1	0.1389
p.K112T	ACH-001991	Primary	CCLE	LILYPD	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51530	DNA replication ATP-dependent helicase/nuclease DNA2	LIG_APCC_ABBA_1	117:122	LILYPD	APC,CDC20,FZR1	0.5095	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons