DegronMD - P51580(TPMT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E109G	TCGA-13-0920	OV	TCGA	NLSYSEEP	CBL_PTK	104:111	Mutation altering degron motif	0.6087
p.E109G	DO28099	OV	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation altering degron motif	0.6087
p.E114K	TCGA-AJ-A5DW	UCEC	TCGA	NLSYSEEP	CBL_PTK	104:111	Mutation rewiring degron network	0.25
p.E114K	TCGA-DK-A6AW	BLCA	TCGA	NLSYSEEP	CBL_PTK	104:111	Mutation rewiring degron network	0.25
p.E114K	DO48566	BLCA	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation rewiring degron network	0.25
p.E114K	DO50075	UCEC	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation rewiring degron network	0.25
p.P111S	TCGA-AP-A1DK	UCEC	TCGA	NLSYSEEP	CBL_PTK	104:111	Mutation altering degron motif	0.6752
p.P111S	DO42033	UCEC	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation altering degron motif	0.6752
p.K119T	TCGA-AX-A05Z	UCEC	TCGA	NLSYSEEP	CBL_PTK	104:111	Mutation substituting flanking lysine	0.2222
p.K119T	DO40884	UCEC	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation substituting flanking lysine	0.2222
p.K119T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	NLSYSEEP	CBL_PTK	104:111	Mutation substituting flanking lysine	0.2222
p.K119T	SIDM00936	Bladder Carcinoma	GDSC	NLSYSEEP	CBL_PTK	104:111	Mutation substituting flanking lysine	0.2222
p.V120I	DO234235	ESAD	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation rewiring degron network	0.0833
p.P116T	DO228976	LICA	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1944
p.Q97K	DO229022	LICA	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation rewiring degron network	0.1389
p.F100L	DO229250	THCA	ICGC	NLSYSEEP	CBL_PTK	104:111	Mutation rewiring degron network	0.2222

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons