DegronMD

Uniprot ID: P51580

Source protein: Thiopurine S-methyltransferase

Source gene: TPMT

Class: CBL_PTK

Location: 104:111

E3 ligase: CBL

DEGRON score: 0.8161

ASA_SCORE: 81.8125

COIL: 0.8383

CONS_SCORE: 0.7956

DSS_SCORE: 0.3483

HELIX: 0.0264

FCONS_SCORE: 0.9787

RIG_SCORE: 0.7951

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E109G	TCGA-13-0920	OV	TCGA	NLSYSEEP	CBL_PTK	0.6087
p.E109G	DO28099	OV	ICGC	NLSYSEEP	CBL_PTK	0.6087
p.E114K	TCGA-AJ-A5DW	UCEC	TCGA	NLSYSEEP	CBL_PTK	0.25
p.E114K	TCGA-DK-A6AW	BLCA	TCGA	NLSYSEEP	CBL_PTK	0.25
p.E114K	DO48566	BLCA	ICGC	NLSYSEEP	CBL_PTK	0.25
p.E114K	DO50075	UCEC	ICGC	NLSYSEEP	CBL_PTK	0.25
p.P111S	TCGA-AP-A1DK	UCEC	TCGA	NLSYSEEP	CBL_PTK	0.6752
p.P111S	DO42033	UCEC	ICGC	NLSYSEEP	CBL_PTK	0.6752
p.K119T	TCGA-AX-A05Z	UCEC	TCGA	NLSYSEEP	CBL_PTK	0.2222
p.K119T	DO40884	UCEC	ICGC	NLSYSEEP	CBL_PTK	0.2222
p.K119T	SIDM00962	Chronic Myelogenous Leukemia	GDSC	NLSYSEEP	CBL_PTK	0.2222
p.K119T	SIDM00936	Bladder Carcinoma	GDSC	NLSYSEEP	CBL_PTK	0.2222
p.V120I	DO234235	ESAD	ICGC	NLSYSEEP	CBL_PTK	0.0833
p.P116T	DO228976	LICA	ICGC	NLSYSEEP	CBL_PTK	0.1944
p.Q97K	DO229022	LICA	ICGC	NLSYSEEP	CBL_PTK	0.1389
p.F100L	DO229250	THCA	ICGC	NLSYSEEP	CBL_PTK	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51580	Thiopurine S-methyltransferase	CBL_PTK	104:111	NLSYSEEP	CBL	0.8161	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons