DegronMD - P51788(CLCN2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A855G	TCGA-04-1361	OV	TCGA	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.1667
p.E868D	TCGA-A5-A0G2	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.25
p.S865N	TCGA-A6-6653	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.7069
p.T867M	TCGA-AX-A2HD	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.2778
p.R851Q	TCGA-BR-6852	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.0556
p.P852L	TCGA-CM-6170	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.0833
p.D851N	DO219061	BLCA	ICGC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.0556
p.H873Y	SIDM00537	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.1111
p.H873Y	GP5d	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.1111
p.R869Q	PCI-15A	upper aerodigestive tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.2222
p.D865E	YKG-1	central nervous system	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.6758
p.D865E	HSC-2	upper aerodigestive tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.6758
p.D865E	Ca9-22	upper aerodigestive tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.6758
p.D865E	KOPN-8	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.6758
p.D865E	KMRC-20	kidney	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.6758
p.D865E	THP-1	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.6758
p.D865E	RERF-LC-FM	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.6758
p.H856Y	GP5d	large intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation blocking phosphorylation signal	0.6389
p.S863P	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation altering degron motif	0.6752
p.S851P	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.0556
p.R857Q	PCI-15A	upper aerodigestive tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	861:865	Mutation rewiring degron network	0.2222

Kaplan plot for CLCN2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLCN2

UniProt ID: P51788

Entrez ID: 1181

Protein name: Chloride channel protein 2 (ClC-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLCN2 in