DegronMD

Uniprot ID: P51788

Source protein: Chloride channel protein 2

Source gene: CLCN2

Class: DEG_SPOP_SBC_1

Location: 861:865

E3 ligase: SPOP

DEGRON score: 0.98

ASA_SCORE: 80.16

COIL: 0.9426

CONS_SCORE: 0.374

DSS_SCORE: 0.5915

HELIX: 0.045

FCONS_SCORE: 0.996

RIG_SCORE: 0.5984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A855G	TCGA-04-1361	OV	TCGA	ATSSS	DEG_SPOP_SBC_1	0.1667
p.E868D	TCGA-A5-A0G2	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	0.25
p.S865N	TCGA-A6-6653	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	0.7069
p.T867M	TCGA-AX-A2HD	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	0.2778
p.R851Q	TCGA-BR-6852	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	0.0556
p.P852L	TCGA-CM-6170	COAD	TCGA	ATSSS	DEG_SPOP_SBC_1	0.0833
p.D851N	DO219061	BLCA	ICGC	ATSSS	DEG_SPOP_SBC_1	0.0556
p.H873Y	SIDM00537	Colorectal Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	0.1111
p.H873Y	GP5d	large_intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.1111
p.R869Q	PCI-15A	upper_aerodigestive_tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222
p.D865E	YKG-1	central_nervous_system	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6758
p.D865E	HSC-2	upper_aerodigestive_tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6758
p.D865E	Ca9-22	upper_aerodigestive_tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6758
p.D865E	KOPN-8	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6758
p.D865E	KMRC-20	kidney	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6758
p.D865E	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6758
p.D865E	RERF-LC-FM	lung	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6758
p.H856Y	GP5d	large_intestine	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6389
p.S863P	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.6752
p.S851P	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.0556
p.R857Q	PCI-15A	upper_aerodigestive_tract	COSMIC	ATSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A7KAX9	Rho GTPase-activating protein 32	DEG_SPOP_SBC_1	1434:1438	ATSSS	SPOP	0.9982	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	887:891	ATSSS	SPOP	0.9464	More...
O15372	Eukaryotic translation initiation factor 3 subunit H	DEG_SPOP_SBC_1	12:16	ATSSS	SPOP	0.9947	More...
O15481	Melanoma-associated antigen B4	DEG_SPOP_SBC_1	337:341	ATSSS	SPOP	0.9724	More...
O75486	Transcription initiation protein SPT3 homolog	DEG_SPOP_SBC_1	12:16	ATSSS	SPOP	0.9822	More...
P05155	Plasma protease C1 inhibitor	DEG_SPOP_SBC_1	26:30	ATSSS	SPOP	0.9771	More...
P13807	Glycogen [starch] synthase, muscle	DEG_SPOP_SBC_1	714:718	ATSSS	SPOP	0.9984	More...
P20020	Plasma membrane calcium-transporting ATPase 1	DEG_SPOP_SBC_1	1204:1208	ATSSS	SPOP	0.9992	More...
P42566	Epidermal growth factor receptor substrate 15	DEG_SPOP_SBC_1	742:746	ATSSS	SPOP	0.9945	More...
P46100	Transcriptional regulator ATRX	DEG_SPOP_SBC_1	1988:1992	ATSSS	SPOP	0.9482	More...
P51788	Chloride channel protein 2	DEG_SPOP_SBC_1	861:865	ATSSS	SPOP	0.98	More...
Q01814	Plasma membrane calcium-transporting ATPase 2	DEG_SPOP_SBC_1	1227:1231	ATSSS	SPOP	0.999	More...
Q03252	Lamin-B2	DEG_SPOP_SBC_1	417:421	ATSSS	SPOP	0.9957	More...
Q14004	Cyclin-dependent kinase 13	DEG_SPOP_SBC_1	263:267	ATSSS	SPOP	0.9936	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	666:670	ATSSS	SPOP	0.9384	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	53:57	ATSSS	SPOP	0.9856	More...
Q6ZN16	Mitogen-activated protein kinase kinase kinase 15	DEG_SPOP_SBC_1	942:946	ATSSS	SPOP	0.807	More...
Q86VM9	Zinc finger CCCH domain-containing protein 18	DEG_SPOP_SBC_1	716:720	ATSSS	SPOP	0.776	More...
Q86XP3	ATP-dependent RNA helicase DDX42	DEG_SPOP_SBC_1	41:45	ATSSS	SPOP	0.9905	More...
Q8IV53	DENN domain-containing protein 1C	DEG_SPOP_SBC_1	631:635	ATSSS	SPOP	0.9832	More...
Q8IZF2	Adhesion G protein-coupled receptor F5	DEG_SPOP_SBC_1	1330:1334	ATSSS	SPOP	0.8435	More...
Q8N264	Rho GTPase-activating protein 24	DEG_SPOP_SBC_1	623:627	ATSSS	SPOP	0.9987	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	11879:11883	ATSSS	SPOP	0.9996	More...
Q92540	Nonsense-mediated mRNA decay factor SMG7	DEG_SPOP_SBC_1	1063:1067	ATSSS	SPOP	0.9984	More...
Q92859	Neogenin	DEG_SPOP_SBC_1	1330:1334	ATSSS	SPOP	0.9832	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	910:914	ATSSS	SPOP	0.9474	More...
Q96T88	E3 ubiquitin-protein ligase UHRF1	DEG_SPOP_SBC_1	389:393	ATSSS	SPOP	0.5185	More...
Q99250	Sodium channel protein type 2 subunit alpha	DEG_SPOP_SBC_1	1137:1141	ATSSS	SPOP	0.5379	More...
Q99814	Endothelial PAS domain-containing protein 1	DEG_SPOP_SBC_1	472:476	ATSSS	SPOP	0.9851	More...
Q9BTV5	Fibronectin type III and SPRY domain-containing protein 1	DEG_SPOP_SBC_1	487:491	ATSSS	SPOP	0.9287	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	149:153	ATSSS	SPOP	0.9831	More...
Q9H1B7	Probable E3 ubiquitin-protein ligase IRF2BPL	DEG_SPOP_SBC_1	307:311	ATSSS	SPOP	0.9719	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	976:980	ATSSS	SPOP	0.798	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	3039:3043	ATSSS	SPOP	0.9921	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4296:4300	ATSSS	SPOP	0.9858	More...
Q9HC84	Mucin-5B	DEG_SPOP_SBC_1	4723:4727	ATSSS	SPOP	0.9213	More...
Q9NPF0	CD320 antigen	DEG_SPOP_SBC_1	214:218	ATSSS	SPOP	0.9034	More...
Q9NY46	Sodium channel protein type 3 subunit alpha	DEG_SPOP_SBC_1	1135:1139	ATSSS	SPOP	0.9733	More...
Q9UHL9	General transcription factor II-I repeat domain-containing protein 1	DEG_SPOP_SBC_1	248:252	ATSSS	SPOP	0.8868	More...
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	DEG_SPOP_SBC_1	463:467	ATSSS	SPOP	0.9992	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	1152:1156	ATSSS	SPOP	0.9555	More...
A0PJX4	Protein shisa-3 homolog	DEG_SPOP_SBC_1	165:169	ATSSS	SPOP	0.8425	More...
Q9UL36	Zinc finger protein 236	DEG_SPOP_SBC_1	1514:1518	ATSSS	SPOP	0.92	More...
D6RIA3	Uncharacterized protein C4orf54	DEG_SPOP_SBC_1	297:301	ATSSS	SPOP	0.9982	More...
Q5BKX6	Solute carrier family 45 member 4	DEG_SPOP_SBC_1	407:411	ATSSS	SPOP	0.9945	More...
Q6ZMN7	PDZ domain-containing RING finger protein 4	DEG_SPOP_SBC_1	542:546	ATSSS	SPOP	0.764	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	494:498	ATSSS	SPOP	0.9812	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ATSSS

Degron related mutations and impact score

Drug responses associated with CLCN2 mutations

All proteins holding degron of ATSSS