DegronMD - Q8IV53(DENND1C)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q624H	TCGA-06-5416	GBM	TCGA	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.1389
p.S490P	TCGA-2W-A8YY	CESC	TCGA	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.1111
p.D630N	TCGA-A5-A0G2	UCEC	TCGA	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.3056
p.D630N	TCGA-DK-A1AC	BLCA	TCGA	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.3056
p.D630N	DO514	BLCA	ICGC	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.3056
p.D630N	DO41235	UCEC	ICGC	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.3056
p.S627L	TCGA-AN-A046	BRCA	TCGA	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.2222
p.S627L	DO1285	BRCA	ICGC	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.2222
p.M467I	TCGA-AX-A1CE	UCEC	TCGA	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation altering degron motif	0.6507
p.M467I	SIDM00317	Kidney Carcinoma	GDSC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation altering degron motif	0.6507
p.M467I	ACH-000171	Kidney Cancer	CCLE	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation altering degron motif	0.6507
p.M467I	VMRC-RCZ	kidney	COSMIC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation altering degron motif	0.6507
p.E697K	TCGA-B0-5701	KIRC	TCGA	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.2778
p.E697K	TCGA-DA-A1IC	SKCM	TCGA	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.2778
p.E697K	DO16240	KIRC	ICGC	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.2778
p.E697K	DO229054	LICA	ICGC	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.2778
p.E697K	DO37430	SKCM	ICGC	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.2778
p.S704Y	TCGA-BK-A139	UCEC	TCGA	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation altering degron motif	0.712
p.S704Y	DO41716	UCEC	ICGC	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation altering degron motif	0.712
p.S693Y	TCGA-D1-A103	UCEC	TCGA	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.1667
p.S693Y	DO42312	UCEC	ICGC	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.1667
p.K456N	TCGA-D1-A103	UCEC	TCGA	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation substituting flanking lysine	0.1944
p.K456N	DO42312	UCEC	ICGC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation substituting flanking lysine	0.1944
p.A689T	TCGA-D3-A1Q4	SKCM	TCGA	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.0556
p.A689T	DO47631	SKCM	ICGC	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.0556
p.P487S	TCGA-D3-A2JN	SKCM	TCGA	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.1944
p.P484Q	TCGA-FS-A1ZN	SKCM	TCGA	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.2778
p.P484Q	DO38165	SKCM	ICGC	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.2778
p.T700I	TCGA-IB-7651	PAAD	TCGA	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation altering degron motif	0.7078
p.R492H	TCGA-P5-A72U	LGG	TCGA	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.0556
p.R492H	DO219823	LGG	ICGC	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.0556
p.S633C	TCGA-VQ-A91D	STAD	TCGA	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation altering degron motif	0.7541
p.R471H	DO227842	COCA	ICGC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation rewiring degron network	0.3056
p.R471H	DO227842	COCA	ICGC	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.2222
p.R471H	LS-123	large intestine	COSMIC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation rewiring degron network	0.3056
p.R471H	LS-123	large intestine	COSMIC	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.2222
p.G624E	DO233109	GACA	ICGC	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.1389
p.R471C	DO233908	GACA	ICGC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation rewiring degron network	0.3056
p.R471C	DO233908	GACA	ICGC	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.2222
p.A689E	DO228976	LICA	ICGC	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.0556
p.A706E	DO229018	LICA	ICGC	PTPWLS	DEG_SCF_FBW7_1	699:704	Mutation rewiring degron network	0.2778
p.R471S	DO229019	LICA	ICGC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation rewiring degron network	0.3056
p.R471S	DO229019	LICA	ICGC	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.2222
p.P487Q	DO229036	LICA	ICGC	LQRGGSLR	SCF_FBXL2	475:482	Mutation rewiring degron network	0.1944
p.S468G	DO42023	UCEC	ICGC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation altering degron motif	0.6993
p.N625I	SIDM01608	Endometrial Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.1667
p.N625I	ACH-000990	Endometrial/Uterine Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.1667
p.I643M	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.1111
p.I643M	ACH-000925	Lung Cancer	CCLE	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation rewiring degron network	0.1111
p.N462Y	HT55	large intestine	COSMIC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation rewiring degron network	0.25
p.E633K	CP66-MEL	skin	COSMIC	ATSSS	DEG_SPOP_SBC_1	631:635	Mutation altering degron motif	0.7022
p.R466H	23132-87	stomach	COSMIC	LLMYKD	LIG_APCC_ABBA_1	465:470	Mutation altering degron motif	0.8244
p.E479G	TYK-nu	ovary	COSMIC	LQRGGSLR	SCF_FBXL2	475:482	Mutation altering degron motif	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DENND1C

UniProt ID: Q8IV53

Entrez ID: 79958

Protein name: DENN domain-containing protein 1C (Connecdenn 3) (Protein FAM31C)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DENND1C in