DegronMD

Uniprot ID: Q8IV53

Source protein: DENN domain-containing protein 1C

Source gene: DENND1C

Class: SCF_FBXL2

Location: 475:482

E3 ligase: FBXL2

DEGRON score: 0.9517

ASA_SCORE: 92.6

COIL: 0.7736

CONS_SCORE: 0.4214

DSS_SCORE: 0.5088

HELIX: 0.0646

FCONS_SCORE: 1.2022

RIG_SCORE: 0.6852

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S490P	TCGA-2W-A8YY	CESC	TCGA	LQRGGSLR	SCF_FBXL2	0.1111
p.P487S	TCGA-D3-A2JN	SKCM	TCGA	LQRGGSLR	SCF_FBXL2	0.1944
p.P484Q	TCGA-FS-A1ZN	SKCM	TCGA	LQRGGSLR	SCF_FBXL2	0.2778
p.P484Q	DO38165	SKCM	ICGC	LQRGGSLR	SCF_FBXL2	0.2778
p.R492H	TCGA-P5-A72U	LGG	TCGA	LQRGGSLR	SCF_FBXL2	0.0556
p.R492H	DO219823	LGG	ICGC	LQRGGSLR	SCF_FBXL2	0.0556
p.R471H	DO227842	COCA	ICGC	LQRGGSLR	SCF_FBXL2	0.2222
p.R471H	LS-123	large_intestine	COSMIC	LQRGGSLR	SCF_FBXL2	0.2222
p.R471C	DO233908	GACA	ICGC	LQRGGSLR	SCF_FBXL2	0.2222
p.R471S	DO229019	LICA	ICGC	LQRGGSLR	SCF_FBXL2	0.2222
p.P487Q	DO229036	LICA	ICGC	LQRGGSLR	SCF_FBXL2	0.1944
p.E479G	TYK-nu	ovary	COSMIC	LQRGGSLR	SCF_FBXL2	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV53	DENN domain-containing protein 1C	SCF_FBXL2	475:482	LQRGGSLR	FBXL2	0.9517	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons