DegronMD

Uniprot ID: Q8IV53

Source protein: DENN domain-containing protein 1C

Source gene: DENND1C

Class: LIG_APCC_ABBA_1

Location: 465:470

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7564

ASA_SCORE: 90.3833

COIL: 0.6473

CONS_SCORE: 0.273

DSS_SCORE: 0.3625

HELIX: 0.2587

FCONS_SCORE: 0.6713

RIG_SCORE: 0.7764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M467I	TCGA-AX-A1CE	UCEC	TCGA	LLMYKD	LIG_APCC_ABBA_1	0.6507
p.M467I	SIDM00317	Kidney Carcinoma	GDSC	LLMYKD	LIG_APCC_ABBA_1	0.6507
p.M467I	ACH-000171	Kidney Cancer	CCLE	LLMYKD	LIG_APCC_ABBA_1	0.6507
p.M467I	VMRC-RCZ	kidney	COSMIC	LLMYKD	LIG_APCC_ABBA_1	0.6507
p.K456N	TCGA-D1-A103	UCEC	TCGA	LLMYKD	LIG_APCC_ABBA_1	0.1944
p.K456N	DO42312	UCEC	ICGC	LLMYKD	LIG_APCC_ABBA_1	0.1944
p.R471H	DO227842	COCA	ICGC	LLMYKD	LIG_APCC_ABBA_1	0.3056
p.R471H	LS-123	large_intestine	COSMIC	LLMYKD	LIG_APCC_ABBA_1	0.3056
p.R471C	DO233908	GACA	ICGC	LLMYKD	LIG_APCC_ABBA_1	0.3056
p.R471S	DO229019	LICA	ICGC	LLMYKD	LIG_APCC_ABBA_1	0.3056
p.S468G	DO42023	UCEC	ICGC	LLMYKD	LIG_APCC_ABBA_1	0.6993
p.N462Y	HT55	large_intestine	COSMIC	LLMYKD	LIG_APCC_ABBA_1	0.25
p.R466H	23132-87	stomach	COSMIC	LLMYKD	LIG_APCC_ABBA_1	0.8244

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IV53	DENN domain-containing protein 1C	LIG_APCC_ABBA_1	465:470	LLMYKD	APC,CDC20,FZR1	0.7564	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons